Cochrane · systematic review · CD011922
Treatment of epilepsy for people with Alzheimer's disease
Liu, J, Wang, L-N · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
21
current version
GRADE rated
15
No studies
6
Included studies
NR
No studies 6 · 28.6%Ungraded 0 · 0%Very low 15 · 71.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsLevetiracetam compared with lamotrigine for the treatment of epilepsy in people with Alzheimer's disease
Population: people with AD and epileptic seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion with seizure freedom Levetiracetam vs lamotrigine | RR 1.2 [0.53, 2.71] | 1 study · 67 participants | Very low Downgraded: risk of bias |
Proportion with adverse events Levetiracetam vs lamotrigine | RR 0.65 [0.25, 1.74] | 1 study · 67 participants | Very low Downgraded: risk of bias |
Reduction in seizure frequency of 50% or more Levetiracetam vs lamotrigine | RR 1.21 [0.84, 1.75] | 1 study · 67 participants | Very low Downgraded: risk of bias |
Proportion with seizure freedom in dominantly inherited AD Levetiracetam vs lamotrigine | no estimate extracted | NR | No studies |
Change in cognition Levetiracetam vs lamotrigine | no estimate extracted | 1 study · 67 participants | Very low Downgraded: risk of bias |
Change in neuropsychiatric symptoms Levetiracetam vs lamotrigine | no estimate extracted | 1 study · 67 participants | Very low Downgraded: risk of bias |
Improvement in quality of life Levetiracetam vs lamotrigine | no estimate extracted | NR | No studies |
Levetiracetam compared with phenobarbital for the treatment of epilepsy in people with Alzheimer's disease
Population: patients with AD and epileptic seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion with seizure freedom Levetiracetam vs phenobarbital | RR 1.01 [0.47, 2.19] | 1 study · 66 participants | Very low Downgraded: risk of bias |
Proportion with adverse events Levetiracetam vs phenobarbital | RR 0.44 [0.18, 1.07] | 1 study · 66 participants | Very low Downgraded: risk of bias |
Reduction in seizure frequency of 50% or more Levetiracetam vs phenobarbital | RR 1.11 [0.78, 1.56] | 1 study · 66 participants | Very low Downgraded: risk of bias |
Proportion with seizure freedom in dominantly inherited AD Levetiracetam vs phenobarbital | no estimate extracted | NR | No studies |
Change in cognition Levetiracetam vs phenobarbital | no estimate extracted | 1 study · 66 participants | Very low Downgraded: risk of bias |
Change in neuropsychiatric symptoms Levetiracetam vs phenobarbital | no estimate extracted | 1 study · 66 participants | Very low Downgraded: risk of bias |
Improvement in quality of life Levetiracetam vs phenobarbital | no estimate extracted | NR | No studies |
Lamotrigine compared with phenobarbital for the treatment of epilepsy in people with Alzheimer's disease
Population: patients with AD and epileptic seizures
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Proportion with seizure freedom Lamotrigine vs phenobarbital | RR 0.84 [0.35, 2.02] | 1 study · 57 participants | Very low Downgraded: risk of bias |
Proportion with adverse events Lamotrigine vs phenobarbital | RR 0.68 [0.3, 1.53] | 1 study · 57 participants | Very low Downgraded: risk of bias |
Reduction in seizure frequency of 50% or more Lamotrigine vs phenobarbital | RR 0.91 [0.6, 1.38] | 1 study · 57 participants | Very low Downgraded: risk of bias |
Proportion with seizure freedom in dominantly inherited AD Lamotrigine vs phenobarbital | no estimate extracted | NR | No studies |
Change in cognition Lamotrigine vs phenobarbital | no estimate extracted | 1 study · 57 participants | Very low Downgraded: risk of bias |
Change in neuropsychiatric symptoms Lamotrigine vs phenobarbital | no estimate extracted | 1 study · 57 participants | Very low Downgraded: risk of bias |
Improvement in quality of life Lamotrigine vs phenobarbital | no estimate extracted | NR | No studies |