Cochrane · systematic review · CD003032
Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents
Brigo, F, Igwe, SC, Lattanzi, S · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
6
No studies
6
Included studies
NR
No studies 6 · 50%Ungraded 0 · 0%Very low 2 · 16.7%Low 1 · 8.3%Moderate 2 · 16.7%High 1 · 8.3%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsEthosuximide compared to valproate for absence seizures in children and adolescents
Population: absence seizures in children and adolescents
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Seizure freedom at 12 months Ethosuximide vs valproate | no estimate extracted | 4 studies · 365 participants | Moderate Downgraded: risk of bias |
80% or greater reduction in seizure frequency Ethosuximide vs valproate | RR 0.7 [0.19, 2.59] | 1 study · 29 participants | Very low Downgraded: risk of bias, imprecision |
50% or greater reduction in seizure frequency Ethosuximide vs valproate | no estimate extracted | 2 studies · 49 participants | Low Downgraded: risk of bias, imprecision |
Normalisation of the EEG ‐ not reported Ethosuximide vs valproate | no estimate extracted | NR | No studies |
Lamotrigine compared to valproate for absence seizures in children and adolescents
Population: absence seizures in children and adolescents
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Seizure freedom at 12 months Lamotrigine vs valproate | no estimate extracted | 4 studies · 405 participants | Moderate Downgraded: risk of bias |
80% or greater reduction in seizure frequency ‐ not reported Lamotrigine vs valproate | no estimate extracted | NR | No studies |
50% or greater reduction in seizure frequency ‐ not reported Lamotrigine vs valproate | no estimate extracted | NR | No studies |
Normalisation of the EEG Lamotrigine vs valproate | RR 2.39 [1.14, 5.04] | 1 study · 45 participants | Very low Downgraded: risk of bias, imprecision |
Ethosuximide compared to lamotrigine for absence seizures in children and adolescents
Population: absence seizures in children and adolescents
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Seizure freedom at 12 months Ethosuximide vs lamotrigine | RR 0.47 [0.33, 0.67] | 1 study · 300 participants | High |
80% or greater reduction in seizure frequency ‐ not reported Ethosuximide vs lamotrigine | no estimate extracted | NR | No studies |
50% or greater reduction in seizure frequency ‐ not reported Ethosuximide vs lamotrigine | no estimate extracted | NR | No studies |
Normalisation of the EEG ‐ not reported Ethosuximide vs lamotrigine | no estimate extracted | NR | No studies |