evidence/gaps
Cochrane · systematic review · CD001909

Lamotrigine add‐on therapy for drug‐resistant focal epilepsy

Panebianco, M, Bresnahan, R, Marson, AG · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library

Epilepsy3 versionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 7 · 100%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

Show all 3 versions

Summary of findings: lamotrigine versus placebo for drug‐resistant focal epilepsy

Population: participants with drug‐resistant focal epilepsy
7 questions
OutcomeEffectEvidenceStatus / GRADE
50% or greater reduction in seizure frequency (ITT analysis)
Summary of findings: lamotrigine vs placebo
RR 1.8 [1.45, 2.23]12 studies · 1322 participantsModerate
Downgraded: imprecision
Treatment withdrawal
Summary of findings: lamotrigine vs placebo
RR 1.11 [0.91, 1.37]14 studies · 1806 participantsModerate
Downgraded: imprecision
Ataxia
Summary of findings: lamotrigine vs placebo
RR 3.3412 studies · 1525 participantsModerate
Downgraded: imprecision
Dizziness
Summary of findings: lamotrigine vs placebo
RR 1.7613 studies · 1768 participantsModerate
Downgraded: inconsistency
Fatigue
Summary of findings: lamotrigine vs placebo
RR 0.8212 studies · 1552 participantsModerate
Downgraded: imprecision
Nausea
Summary of findings: lamotrigine vs placebo
RR 1.8112 studies · 1486 participantsModerate
Downgraded: imprecision
Diplopia
Summary of findings: lamotrigine vs placebo
RR 3.79 [2.15, 6.68]3 studies · 944 participantsModerate
Downgraded: imprecision