Seizure freedom · absence seizures in children and adolescents
1 finding from 1 review
80% or greater reduction in seizure frequency ‐ not reported · absence seizures in children and adolescents
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
50% or greater reduction in seizure frequency · absence seizures in children and adolescents
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Normalisation of the EEG ‐ not reported · absence seizures in children and adolescents
It is very uncertain whether lamotrigine changes normalisation of the EEG compared with valproate (very low certainty).
1 finding from 1 review
Recurrence of any episodes at one year (hospitalization for any episodes) · bipolar disorder
1 finding from 1 review
Recurrence of manic episode at one year · bipolar disorder
Lamotrigine showed no clear difference in recurrence of manic episode at one year compared with placebo (moderate certainty).
1 finding from 1 review
Recurrence of depressive episode at one year · bipolar disorder
Lamotrigine showed no clear difference in recurrence of depressive episode at one year compared with placebo (moderate certainty).
1 finding from 1 review
Health status and quality of life · bipolar disorder
1 finding from 1 review
Total severity score from depression and mania symptom scores, such as HDRS and the YMRS · bipolar disorder
1 finding from 1 review
Recurrence of any episodes at one year (hospitalization for any episodes) · bipolar disorder
1 finding from 1 review
Recurrence of any episodes at one year (Young Mania Rating Scale (YMRS) total score ≥15 for manic episode) · bipolar disorder
It is very uncertain whether lamotrigine changes recurrence of any episodes at one year (Young Mania Rating Scale… compared with lithium (very low certainty).
1 finding from 1 review
Recurrence of any episodes at one year (Montgomery‐Asberg Depression Rating Scale (MADRS) total score ≥15 for depressive episode; Hamilton Depression Rating Scale (HDRS) total score ≥14 for depressive episode) · bipolar disorder
Lamotrigine showed no clear difference in recurrence of any episodes at one year (Montgomery‐Asberg Depression… compared with lithium (low certainty).
1 finding from 1 review
Recurrence of any episodes at one year for clinical worsening with additional psychotropics (mood stabilizers, antidepressants, antipsychotics or benzodiazepines) · bipolar disorder
Lamotrigine showed no clear difference in recurrence of any episodes at one year for clinical worsening with… compared with lithium (moderate certainty).
1 finding from 1 review
Recurrence of any episodes at one year (active suicidal behavior) · bipolar disorder
It is very uncertain whether lamotrigine changes recurrence of any episodes at one year (active suicidal behavior) compared with lithium (very low certainty).
1 finding from 1 review
Treatment withdrawal · bipolar disorder
1 finding from 1 review
Recurrence of any episodes at one year (Young Mania Rating Scale (YMRS) total score ≥15 for manic episode) · bipolar disorder
Lamotrigine may leads to lower recurrence of any episodes at one year (Young Mania Rating Scale… compared with placebo (low certainty).
1 finding from 1 review
Withdrawal from treatment due to any reason, 6‐12 months after intervention initiation (long term) · bipolar disorder
Lamotrigine showed no clear difference in withdrawal from treatment due to any reason, 6‐12 months after… compared with lithium (moderate certainty).
1 finding from 1 review
Any reported adverse effects up to 12 weeks after starting treatment (short term) · bipolar disorder
1 finding from 1 review
Any reported adverse effects 6‐12 months after initiating the intervention (long term) · bipolar disorder
Lamotrigine probably leads to lower any reported adverse effects 6‐12 months after initiating the… compared with lithium (moderate certainty).
1 finding from 1 review
Recurrence of manic episode at one year · bipolar disorder
Lamotrigine probably leads to higher recurrence of manic episode at one year compared with lithium (moderate certainty).
1 finding from 1 review