What do systematic reviews say?

Inhaled corticosteroids vs placebo

• Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Inhaled corticosteroids vs placebo

• Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 295 participants
  Low

A boost of inhaled corticosteroids vs usual care

A boost of inhaled corticosteroids showed no clear difference in exacerbations compared with usual care (moderate certainty).

• Interventions for autumn exacerbations of asthma in children 2018 · Cochrane Headline outcomes only
  OR 0.86 [0.32, 2.3]
  1 study · 173 participants
  Moderate

A boost of inhaled corticosteroids vs usual care

A boost of inhaled corticosteroids showed no clear difference in adverse events compared with usual care (moderate certainty).

• Interventions for autumn exacerbations of asthma in children 2018 · Cochrane Headline outcomes only
  OR 0.67 [0.34, 1.33]
  1 study · 176 participants
  Moderate

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs beclomethasone

Effects of different inhaled corticosteroids on growth in children… may leads to higher linear growth velocity (cm/year) compared with beclomethasone (low certainty).

• Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth 2019 · Cochrane Headline outcomes only
  MD 0.81 [0.46, 1.16]
  1 study · 23 participants
  Low

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs budesonide

It is very uncertain whether effects of different inhaled corticosteroids on growth in children… changes linear growth velocity (cm/year) compared with budesonide (very low certainty).

• Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth 2019 · Cochrane Headline outcomes only
  MD 0.39
  2 studies · 236 participants
  Very low

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs budesonide

Effects of different inhaled corticosteroids on growth in children… probably leads to higher change in height (cm) over a period of time compared with budesonide (moderate certainty).

• Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth 2019 · Cochrane Headline outcomes only
  MD 0.97 [0.62, 1.32]
  2 studies · 359 participants
  Moderate

Inhaled steroids vs systemic corticosteroids

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age among all randomised compared with systemic corticosteroids (moderate certainty).

• Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight… 2017 · Cochrane Headline outcomes only
  RR 1.09 [0.88, 1.35]
  1 study · 278 participants
  Moderate

Inhaled steroids vs systemic corticosteroids

Inhaled steroids showed no clear difference in death or BPD at 28 days compared with systemic corticosteroids (low certainty).

• Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight… 2017 · Cochrane Headline outcomes only
  RR 1.05 [0.93, 1.2]
  2 studies · 294 participants
  Low

Inhaled steroids vs systemic corticosteroids

Inhaled steroids showed no clear difference in BPD at 36 weeks' postmenstrual age compared with systemic corticosteroids (moderate certainty).

• Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight… 2017 · Cochrane Headline outcomes only
  RR 1.45 [0.99, 2.11]
  1 study · 278 participants
  Moderate

Inhaled steroids vs systemic corticosteroids

Inhaled steroids showed no clear difference in BPD at 28 days compared with systemic corticosteroids (low certainty).

• Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight… 2017 · Cochrane Headline outcomes only
  RR 1.21 [0.98, 1.48]
  2 studies · 294 participants
  Low

Inhaled steroids vs systemic steroids

Inhaled steroids showed no clear difference in death or BPD at 36 weeks' postmenstrual age compared with systemic steroids (moderate certainty).

• Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
  RR 1.04 [0.86, 1.26]
  1 study · 292 participants
  Moderate
• Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
  RR 0.94 [0.83, 1.05]
  1 study · 78 participants
  Low

Inhaled steroids vs systemic steroids

Inhaled steroids probably leads to lower diastolic blood pressure > 95th percentile at 7 years compared with systemic steroids (moderate certainty).

• Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 69 participants
  Moderate

Inhaled steroids vs systemic steroids

Inhaled steroids showed no clear difference in ever diagnosed as asthmatic by 7 years compared with systemic steroids (moderate certainty).

• Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
  RR 0.87 [0.55, 1.39]
  1 study · 73 participants
  Moderate

Inhaled steroids vs systemic steroids

Inhaled steroids showed no clear difference in BPD at 36 weeks' postmenstrual age compared with systemic steroids (low certainty).

• Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
  RR 1.08 [0.88, 1.32]
  3 studies · 429 participants
  Low

Inhaled steroids vs systemic steroids

Inhaled steroids showed no clear difference in hyperglycaemia compared with systemic steroids (low certainty).

• Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
  RR 0.86 [0.61, 1.22]
  3 studies · 429 participants
  Low

Inhaled steroids vs systemic steroids

Inhaled steroids may leads to lower hypertension compared with systemic steroids (low certainty).

• Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
  RR 0.86
  3 studies · 429 participants
  Low

Inhaled steroids vs systemic steroids

Inhaled steroids showed no clear difference in general conceptual ability (GCA) score at 7 years The test has a… compared with systemic steroids (moderate certainty).

• Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 74 participants
  Moderate

Inhaled steroids vs systemic steroids

Inhaled steroids showed no clear difference in moderate/severe disability at 7 years compared with systemic steroids (moderate certainty).

• Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
  RR 1.4 [0.49, 4.01]
  1 study · 74 participants
  Moderate

Inhaled steroids vs systemic steroids

Inhaled steroids showed no clear difference in death or moderate/severe disability at 7 years compared with systemic steroids (moderate certainty).

• Inhaled versus systemic corticosteroids for the treatment of bronchopulmonary dysplasia in ventilated very low birth… 2017 · Cochrane Headline outcomes only
  RR 1.01 [0.65, 1.58]
  1 study · 107 participants
  Moderate