Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

901 questions · 1,073 findings · 138 reviews

No studies found 166 · 15.5%GRADE not reported 310 · 28.9%Very low 213 · 19.9%Low 227 · 21.2%Moderate 132 · 12.3%High 25 · 2.3%

Combined OST and high NSP vs no OST and low/no NSP

HCV incidence adjusted analyses number of HCV seroconversion · people who inject drugs

Combined OST and high NSP may leads to lower HCV incidence adjusted analyses number of HCV seroconversions compared with no OST and low/no NSP (low certainty).

1 finding from 1 review

High dose of manipulation vs low dose of manipulation

Chronic neck pain and CGH Intermediate‐term · patients with chronic neck pain with cervicogenic headache (CGH)

High dose of manipulation showed no clear difference in chronic neck pain and CGH Intermediate‐term compared with low dose of manipulation (moderate certainty).

1 finding from 1 review

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Ambulation · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids showed no clear difference in ambulation compared with moderate‐dose or no corticosteroids (low certainty).

1 finding from 1 review

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Survival (long term) Over two years · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids showed no clear difference in survival (long term) Over two years compared with moderate‐dose or no corticosteroids (low certainty).

1 finding from 1 review

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Pain reduction · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids showed no clear difference in pain reduction compared with moderate‐dose or no corticosteroids (low certainty).

1 finding from 1 review

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Urinary continence One week after treatment · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids showed no clear difference in urinary continence One week after treatment compared with moderate‐dose or no corticosteroids (low certainty).

1 finding from 1 review

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Serious adverse events · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids probably leads to higher serious adverse events compared with moderate‐dose or no corticosteroids (moderate certainty).

1 finding from 1 review

High edentulism prevalence vs Not applicable

Oral health-related quality of life · people aged 60 years and older living in the community

No statistically significant difference in OHRQoL was reported by edentulism prevalence.

1 finding from 1 review

Higher waist circumference vs Lower waist circumference

Dental caries in children · Children (approx. 4-18 years)

Waist circumference was not significantly associated with childhood dental caries (pooled OR 1.08, 95% CI 0.90 to 1.30; I2=47.7%); ungraded.

1 finding from 1 review

Higher‐dose anticoagulants vs lower‐dose anticoagulants

Necessity for additional respiratory support · people hospitalised with COVID‐19

It is very uncertain whether higher‐dose anticoagulants changes necessity for additional respiratory support compared with lower‐dose anticoagulants (very low certainty).

1 finding from 1 review