Serum ferritin levels did not differ significantly between children with ECC and caries-free children (mean difference -5.80, 95% CI -11.97 to 0.37); ungraded.
Mean corpuscular volume was significantly lower in children with ECC than in caries-free children (mean difference -3.72, 95% CI -6.65 to -0.79); ungraded.
It is very uncertain whether early active flexion plus controlled passive exercise regimen changes adverse events: participants incurring one or more adverse events compared with early controlled passive exercise regimen (very low certainty).
It is very uncertain whether early active flexion plus controlled passive exercise regimen changes adverse event (tendon rupture) compared with early controlled passive exercise regimen (very low certainty).
It is very uncertain whether prophylactic or very early CPAP changes failed treatment defined as recurrent apnoea, hypoxia, hypercarbia… compared with supportive care (very low certainty).
Prophylactic or very early CPAP showed no clear difference in bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency… compared with supportive care (moderate certainty).
Prophylactic or very early CPAP showed no clear difference in death at any time compared with supportive care (moderate certainty).
Prophylactic or very early CPAP showed no clear difference in combined outcome of death and bronchopulmonary dysplasia defined as… compared with supportive care (low certainty).
Prophylactic or very early CPAP showed no clear difference in pulmonary air leak defined as pneumothorax compared with supportive care (low certainty).
Prophylactic or very early CPAP showed no clear difference in intraventricular haemorrhage grade 3 or 4 compared with supportive care (low certainty).
The review found no eligible studies for this question.
Early inhaled steroid (< 2 weeks) probably leads to lower CLD at 36 weeks' PMA compared with placebo (among survivors) (moderate certainty).
Early inhaled steroids (< 2 weeks) showed no clear difference in CLD at 36 weeks' PMA oxygen dependency at 36 weeks' PMA compared with placebo (among all randomised) (moderate certainty).
Early inhaled steroids (< 2 weeks) probably leads to lower death by, or CLD at, 36 weeks' PMA Death or oxygen dependency at 36… compared with placebo (among all randomised) (moderate certainty).
Specialised early intervention (SEI) may leads to higher global state: recovery (assessed by proportion recovered, as defined… compared with treatment (low certainty).
Specialised early intervention (SEI) probably leads to lower service use: disengagement from services (assessed by proportion… compared with treatment (moderate certainty).
Specialised early intervention (SEI) showed no clear difference in service use: admission to psychiatric hospital (assessed by… compared with treatment (low certainty).