Findings

What do systematic reviews say?

415 questions · 442 findings · 58 reviews

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No studies found 70 · 15.8%GRADE not reported 19 · 4.3%Very low 99 · 22.4%Low 137 · 31%Moderate 86 · 19.5%High 31 · 7%

A boost of inhaled corticosteroids vs usual care

Exacerbations · autumn asthma exacerbations in children

A boost of inhaled corticosteroids showed no clear difference in exacerbations compared with usual care (moderate certainty).

1 finding from 1 review

Interventions for autumn exacerbations of asthma in children 2018 · Cochrane Headline outcomes only
OR 0.86 [0.32, 2.3]
1 study · 173 participants
Moderate

A boost of inhaled corticosteroids vs usual care

Adverse events · autumn asthma exacerbations in children

A boost of inhaled corticosteroids showed no clear difference in adverse events compared with usual care (moderate certainty).

1 finding from 1 review

Interventions for autumn exacerbations of asthma in children 2018 · Cochrane Headline outcomes only
OR 0.67 [0.34, 1.33]
1 study · 176 participants
Moderate

Corticosteroids vs placebo

Mean GI symptom scores · Men with prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Corticosteroids vs placebo

Acute and late GI toxicity (grade 2+) · Men with prostate cancer

It is very uncertain whether summary of findings: Corticosteroids changes acute and late GI toxicity (grade 2+) compared with placebo (very low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 0.85 [0.62, 1.15]
1 study · 126 participants
Very low

Corticosteroids vs placebo

Diarrhoea (grade 2+) · Men with prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Corticosteroids vs placebo

QoL · Men with prostate cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs beclomethasone

Linear growth velocity (cm/year) · children up to 18 years of age with persistent asthma

Effects of different inhaled corticosteroids on growth in children… may leads to higher linear growth velocity (cm/year) compared with beclomethasone (low certainty).

1 finding from 1 review

Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth 2019 · Cochrane Headline outcomes only
MD 0.81 [0.46, 1.16]
1 study · 23 participants
Low

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs budesonide

Linear growth velocity (cm/year) · children up to 18 years of age with persistent asthma

It is very uncertain whether effects of different inhaled corticosteroids on growth in children… changes linear growth velocity (cm/year) compared with budesonide (very low certainty).

1 finding from 1 review

Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth 2019 · Cochrane Headline outcomes only
MD 0.39
2 studies · 236 participants
Very low

Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs budesonide

Change in height · children up to 18 years of age with persistent asthma

Effects of different inhaled corticosteroids on growth in children… probably leads to higher change in height (cm) over a period of time compared with budesonide (moderate certainty).

1 finding from 1 review

Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth 2019 · Cochrane Headline outcomes only
MD 0.97 [0.62, 1.32]
2 studies · 359 participants
Moderate

Iontophoretically applied corticosteroids

Outcome not reported · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
The review noted the noticeable absence of evidence for iontophoretically applied corticosteroids; no eligible RCT evaluated it (Discussion).
0 studies
No studies found

Strategies to increase use of antenatal corticosteroids vs usual care

Perinatal mortality · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher perinatal death (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.11 [1.04, 1.19]
1 study · 100705 participants
Moderate

Strategies to increase use of antenatal corticosteroids vs usual care

Offspring mortality, early neurodevelopmental morbidity or late neurodevelopmental morbidity · women at risk of preterm birth

The review found no eligible studies for this question.

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Strategies to increase use of antenatal corticosteroids vs usual care

Offspring mortality or severe neonatal morbidity · women at risk of preterm birth

The review found no eligible studies for this question.

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Strategies to increase use of antenatal corticosteroids vs usual care

Neonatal death (death within the first 28 days of life) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher neonatal death before 28 days (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.12 [1.02, 1.23]
1 study · 100705 participants
Moderate

Strategies to increase use of antenatal corticosteroids vs usual care

Stillbirth · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids probably leads to higher stillbirth (at population level) compared with routine (usual) care (moderate certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.11 [1.02, 1.21]
1 study · 100705 participants
Moderate

Strategies to increase use of antenatal corticosteroids vs usual care

Appropriate ACS treatment (women) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher appropriate ACS treatment (women) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 4.34 [3.59, 5.25]
1 study · 4389 participants
Low

Strategies to increase use of antenatal corticosteroids vs usual care

Inappropriate ACS treatment (women) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher inappropriate ACS treatment (women) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 9.11 [8.04, 10.33]
1 study · 89237 participants
Low

Strategies to increase use of antenatal corticosteroids vs usual care

Maternal infection or inflammation (at population level) · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids may leads to higher maternal infection or inflammation (at population level) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.49 [1.32, 1.68]
1 study · 99742 participants
Low

Strategies to increase use of antenatal corticosteroids vs usual care

Maternal death · women at risk of preterm birth

Strategies to increase use of antenatal corticosteroids showed no clear difference in maternal mortality (at population level) compared with routine (usual) care (low certainty).

1 finding from 1 review

Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth 2020 · Cochrane Headline outcomes only
RR 1.11 [0.64, 1.92]
1 study · 99742 participants
Low

Corticosteroids vs control

Infectious complications · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: corticosteroids changes overall infectious complications within 30 days of surgery compared with control (very low certainty).

3 findings from 1 review

Risk of postoperative infectious complications from medical therapies in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
OR 1.4 [1.23, 1.6]
41 studies · 41 participants
Very low
Risk of postoperative infectious complications from medical therapies in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
OR 1.7 [1.38, 2.09]
17 studies · 17 participants
Low
Risk of postoperative infectious complications from medical therapies in inflammatory bowel disease 2020 · Cochrane Headline outcomes only
OR 1.22 [1.03, 1.45]
24 studies · 24 participants
Very low