Cochrane · systematic review · CD013256
Risk of postoperative infectious complications from medical therapies in inflammatory bowel disease
Law, CCY, Bell, C, Koh, D, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
GutAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
30
current version
GRADE rated
27
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 3 · 10%Very low 24 · 80%Low 3 · 10%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Risk of postoperative infectious complications: corticosteroids compared to control
Population: inflammatory bowel disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall infectious complications within 30 days of surgery Risk of postoperative infectious complications: corticosteroids vs control | OR 1.4 [1.23, 1.6] | 41 studies · 41 participants | Very low |
Overall infectious complications within 30 days of surgery (Adjusted Analysis) Risk of postoperative infectious complications: corticosteroids vs control | OR 1.7 [1.38, 2.09] | 17 studies · 17 participants | Low Downgraded: imprecision, inconsistency |
Overall infectious complications within 30 days of surgery (Unadjusted Analysis) Risk of postoperative infectious complications: corticosteroids vs control | OR 1.22 [1.03, 1.45] | 24 studies · 24 participants | Very low Downgraded: imprecision, inconsistency |
Incisional infections and wound dehiscence within 30 days of surgery Risk of postoperative infectious complications: corticosteroids vs control | OR 1.41 [0.72, 2.74] | 7 studies · 7 participants | Very low |
Intra‐abdominal infectious complications within 30 days of surgery Risk of postoperative infectious complications: corticosteroids vs control | OR 1.53 [1.28, 1.84] | 28 studies · 28 participants | Very low |
Extra‐abdominal infections within 30 days of surgery Risk of postoperative infectious complications: corticosteroids vs control | OR 1.23 [0.97, 1.55] | 4 studies · 4 participants | Very low |
Risk of postoperative infectious complications: 5‐ASA compared to control
Population: inflammatory bowel disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall infectious complications within 30 days of surgery Risk of postoperative infectious complications: 5‐ASA vs control | OR 0.76 [0.51, 1.14] | 6 studies · 6 participants | Very low Downgraded: risk of bias, imprecision |
Overall infectious complications within 30 days of surgery (Adjusted Analysis) Risk of postoperative infectious complications: 5‐ASA vs control | no estimate extracted | 0 studies · 0 participants | Ungraded |
Overall infectious complications within 30 days of surgery (Unadjusted Analysis) Risk of postoperative infectious complications: 5‐ASA vs control | OR 0.76 [0.51, 1.14] | 6 studies · 6 participants | Very low Downgraded: risk of bias, imprecision |
Incisional infections and wound dehiscence within 30 days of surgery Risk of postoperative infectious complications: 5‐ASA vs control | OR 0.53 [0.3, 0.95] | 1 study · 1 participants | Ungraded |
Intra‐abdominal infectious complications within 30 days of surgery Risk of postoperative infectious complications: 5‐ASA vs control | OR 0.77 [0.45, 1.33] | 3 studies · 3 participants | Very low Downgraded: risk of bias, imprecision |
Extra‐abdominal infections within 30 days of surgery 1 Risk of postoperative infectious complications: 5‐ASA vs control | no estimate extracted | 0 studies · 0 participants | Ungraded |
Risk of postoperative infectious complications: immunomodulators compared to control
Population: inflammatory bowel disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall infectious complications within 30 days of surgery Risk of postoperative infectious complications: immunomodulators vs control | OR 1.11 [0.97, 1.26] | 31 studies · 31 participants | Very low Downgraded: risk of bias |
Overall infectious complications within 30 days of surgery (Adjusted Analysis) Risk of postoperative infectious complications: immunomodulators vs control | OR 1.29 [0.95, 1.76] | 9 studies · 9 participants | Low Downgraded: risk of bias, imprecision |
Overall infectious complications within 30 days of surgery (Unadjusted Analysis) Risk of postoperative infectious complications: immunomodulators vs control | OR 1.07 [0.93, 1.24] | 22 studies · 22 participants | Very low Downgraded: risk of bias |
Incisional infections and wound dehiscence within 30 days of surgery Risk of postoperative infectious complications: immunomodulators vs control | OR 1.35 [0.96, 1.89] | 11 studies · 11 participants | Very low Downgraded: risk of bias |
Intra‐abdominal infectious complications within 30 days of surgery Risk of postoperative infectious complications: immunomodulators vs control | OR 0.86 [0.66, 1.12] | 20 studies · 20 participants | Very low Downgraded: risk of bias |
Extra‐abdominal infections within 30 days of surgery Risk of postoperative infectious complications: immunomodulators vs control | OR 1.17 [0.8, 1.71] | 4 studies · 4 participants | Very low Downgraded: risk of bias |
Risk of postoperative infectious complications: anti‐TNF agents compared to control
Population: inflammatory bowel disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall infectious complications within 30 days of surgery Risk of postoperative infectious complications: anti‐TNF agents vs control | OR 1.27 [1.09, 1.47] | 54 studies · 54 participants | Very low Downgraded: risk of bias |
Overall infectious complications within 30 days of surgery (Adjusted Analysis) Risk of postoperative infectious complications: anti‐TNF agents vs control | OR 1.6 [1.2, 2.13] | 17 studies · 17 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Overall infectious complications within 30 days of surgery (Unadjusted Analysis) Risk of postoperative infectious complications: anti‐TNF agents vs control | OR 1.14 [0.96, 1.36] | 37 studies · 37 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Incisional infections and wound dehiscence within 30 days of surgery Risk of postoperative infectious complications: anti‐TNF agents vs control | OR 1.18 [0.83, 1.68] | 24 studies · 24 participants | Very low Downgraded: risk of bias |
Intra‐abdominal infectious complications within 30 days of surgery Risk of postoperative infectious complications: anti‐TNF agents vs control | OR 1.38 [1.04, 1.82] | 39 studies · 39 participants | Very low Downgraded: risk of bias |
Extra‐abdominal infections within 30 days of surgery Risk of postoperative infectious complications: anti‐TNF agents vs control | OR 1.34 [0.96, 1.87] | 13 studies · 13 participants | Very low Downgraded: risk of bias |
Risk of postoperative infectious complications: anti‐integrin agents compared to control
Population: inflammatory bowel disease
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall infectious complications within 30 days of surgery Risk of postoperative infectious complications: anti‐integrin agents vs control | OR 1.11 [0.76, 1.62] | 9 studies · 9 participants | Very low Downgraded: risk of bias |
Overall infectious complications within 30 days of surgery (Adjusted Analysis) Risk of postoperative infectious complications: anti‐integrin agents vs control | OR 1.04 [0.79, 1.36] | 2 studies · 2 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Overall infectious complications within 30 days of surgery (Unadjusted Analysis) Risk of postoperative infectious complications: anti‐integrin agents vs control | OR 1.06 [0.54, 2.1] | 7 studies · 7 participants | Very low Downgraded: risk of bias |
Incisional infections and wound dehiscence within 30 days of surgery Risk of postoperative infectious complications: anti‐integrin agents vs control | OR 1.64 [0.77, 3.5] | 6 studies · 6 participants | Very low Downgraded: risk of bias |
Intra‐abdominal infectious complications within 30 days of surgery Risk of postoperative infectious complications: anti‐integrin agents vs control | OR 0.4 [0.14, 1.2] | 5 studies · 5 participants | Very low Downgraded: risk of bias |
Extra‐abdominal infections within 30 days of surgery Risk of postoperative infectious complications: anti‐integrin agents vs control | OR 1.15 [0.43, 3.08] | 5 studies · 5 participants | Very low Downgraded: risk of bias |