Cochrane · systematic review · CD013633
Strategies for optimising antenatal corticosteroid administration for women with anticipated preterm birth
Rohwer, AC, Oladapo, OT, Hofmeyr, GJ · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
7
No studies
2
Included studies
NR
No studies 2 · 22.2%Ungraded 0 · 0%Very low 0 · 0%Low 4 · 44.4%Moderate 3 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Strategies to increase use of antenatal corticosteroids versus routine (usual) care for optimising antenatal corticosteroid administration for anticipated preterm birth
Population: women at risk of preterm birth
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Perinatal death (at population level) Strategies to increase use of antenatal corticosteroids vs routine (usual) care | RR 1.11 [1.04, 1.19] | 1 study · 100705 participants | Moderate Downgraded: risk of bias |
Offspring mortality, early neurodevelopmental morbidity or late neurodevelopmental morbidity Strategies to increase use of antenatal corticosteroids vs routine (usual) care | no estimate extracted | NR | No studies |
Offspring mortality or severe neonatal morbidity Strategies to increase use of antenatal corticosteroids vs routine (usual) care | no estimate extracted | NR | No studies |
Neonatal death before 28 days (at population level) Strategies to increase use of antenatal corticosteroids vs routine (usual) care | RR 1.12 [1.02, 1.23] | 1 study · 100705 participants | Moderate Downgraded: risk of bias |
Stillbirth (at population level) Strategies to increase use of antenatal corticosteroids vs routine (usual) care | RR 1.11 [1.02, 1.21] | 1 study · 100705 participants | Moderate Downgraded: risk of bias |
Appropriate ACS treatment (women) Strategies to increase use of antenatal corticosteroids vs routine (usual) care | RR 4.34 [3.59, 5.25] | 1 study · 4389 participants | Low Downgraded: risk of bias, indirectness |
Inappropriate ACS treatment (women) Strategies to increase use of antenatal corticosteroids vs routine (usual) care | RR 9.11 [8.04, 10.33] | 1 study · 89237 participants | Low Downgraded: risk of bias, indirectness |
Maternal infection or inflammation (at population level) Strategies to increase use of antenatal corticosteroids vs routine (usual) care | RR 1.49 [1.32, 1.68] | 1 study · 99742 participants | Low Downgraded: risk of bias |
Maternal mortality (at population level) Strategies to increase use of antenatal corticosteroids vs routine (usual) care | RR 1.11 [0.64, 1.92] | 1 study · 99742 participants | Low Downgraded: risk of bias |