Admission to hospital or death · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination
Inhaled corticosteroids plus standard care probably leads to lower admission to hospital or death compared with standard care (with or without placebo) (moderate certainty).
1 finding from 1 review
Resolution of symptoms · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination
Inhaled corticosteroids plus standard care probably leads to higher symptom resolution: all initial symptoms resolved at day 14 compared with standard care (with or without placebo) (moderate certainty).
1 finding from 1 review
Time to symptom resolution · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination
Inhaled corticosteroids plus standard care showed no clear difference in symptom resolution: duration to symptoms resolved compared with standard care (with or without placebo) (low certainty).
1 finding from 1 review
Serious adverse events · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination
It is very uncertain whether inhaled corticosteroids plus standard care changes serious adverse events compared with standard care (with or without placebo) (very low certainty).
1 finding from 1 review
Adverse events · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination
Inhaled corticosteroids plus standard care showed no clear difference in adverse events compared with standard care (with or without placebo) (low certainty).
1 finding from 1 review
Infections · adults with a confirmed diagnosis of mild COVID‐19, of whom only 10% (219/2132) participants had received ≥ 1 vaccination
Inhaled corticosteroids plus standard care showed no clear difference in infections compared with standard care (with or without placebo) (low certainty).
1 finding from 1 review
Perinatal mortality · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids leads to lower perinatal death (composite of fetal death (in utero death) and… compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.85 [0.77, 0.93]
Studies not reported
High
Neonatal death (baby born alive at any gestation and dies within 28 days) · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids leads to lower neonatal death (infants born with signs of life who die within the… compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.78 [0.7, 0.87]
Studies not reported
High
Respiratory distress syndrome · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids leads to lower respiratory distress syndrome№ of participants: 11,183(26 RCTs) compared with placebo or no treatment (high certainty).
1 finding from 1 review
RR 0.71 [0.65, 0.78]
Studies not reported
High
Intraventricular haemorrhage · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids probably leads to lower intraventricular haemorrhage (IVH)№ of participants: 8475(12 RCTs) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 0.58 [0.45, 0.75]
Studies not reported
Moderate
Mean birthweight · infants born of women at risk of preterm birth
1 finding from 1 review
no estimate extracted
Studies not reported
High
Developmental delay in childhood№ of participants: 600 (3 RCTs). Age at · infants born of women at risk of preterm birth
Neonatal and child outcomes: corticosteroids probably leads to lower developmental delay in childhood№ of participants: 600 (3 RCTs). Age… compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
RR 0.51 [0.27, 0.97]
Studies not reported
Moderate
FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis
1 finding from 1 review
FVC (% predicted) Change from baseline · adults and children with cystic fibrosis
1 finding from 1 review
BHR: change in PC20 values · adults and children with cystic fibrosis
1 finding from 1 review
Change in exercise tolerance · adults and children with cystic fibrosis
1 finding from 1 review
Respiratory exacerbations: number of days on intravenous antibiotics for respiratory exacerbations · adults and children with cystic fibrosis
It is very uncertain whether summary of findings: inhaled corticosteroids changes respiratory exacerbations: number of days on intravenous antibiotics… compared with placebo (very low certainty).
1 finding from 1 review
Quality of life: Quality of Well Being score change from baseline · adults and children with cystic fibrosis
1 finding from 1 review
Adverse effects · adults and children with cystic fibrosis
1 finding from 1 review
Length of hospital stay · patients age 10 years and older with periorbital or orbital cellulitis
It is very uncertain whether standard treatment plus systemic corticosteroids changes length of hospital stay compared with standard treatment alone (very low certainty).
1 finding from 1 review