Findings

What do systematic reviews say?

13 questions · 13 findings · 12 reviews

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No studies found 2 · 15.4%GRADE not reported 2 · 15.4%Very low 1 · 7.7%Low 4 · 30.8%Moderate 4 · 30.8%High 0 · 0%

Corticosteroids vs no corticosteroid use

Incidence of any serious adverse effects attributable to the administration of corticosteroids · children diagnosed with Kawasaki disease

1 finding from 1 review

Corticosteroids for the treatment of Kawasaki disease in children 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 737 participants
Moderate

Corticosteroids vs placebo or no treatment

Adverse effects · Bell's palsy

Corticosteroids showed no clear difference in adverse effects compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Corticosteroids for Bell's palsy (idiopathic facial paralysis) 2016 · Cochrane Headline outcomes only
RR 1.04 [0.71, 1.51]
3 studies · 715 participants
Moderate

Corticosteroids vs placebo

Adverse effects · Patients with idiopathic acute vestibular dysfunction (vestibular neuritis)

1 finding from 1 review

Corticosteroids for the treatment of idiopathic acute vestibular dysfunction (vestibular neuritis) 2011 · Cochrane Headline outcomes only
no estimate extracted
1 study · 73 participants
Moderate

Corticosteroids vs no corticosteroid use

Adverse effects leading to discontinuation of SJT/TEN therapy ‐ not reported · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Systemic interventions for treatment of Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN… 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

Corticosteroid related adverse events · the woman

1 finding from 1 review

Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1477 participants
Low

Systemic corticosteroids vs placebo

Adverse effects · children with acute otitis media

1 finding from 1 review

Systemic corticosteroids for acute otitis media in children 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Topical corticosteroids vs placebo or no treatment

Adverse effects (any) · boys up to 18 years old with phimosis

Topical corticosteroids showed no clear difference in adverse effects (any) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Topical corticosteroids for treating phimosis in boys 2024 · Cochrane Headline outcomes only
RR 0.28 [0.03, 2.62]
11 studies · 1091 participants
Low

Inhaled corticosteroids vs placebo

Adverse effects · adults and children with cystic fibrosis

1 finding from 1 review

Inhaled corticosteroids for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 295 participants
Low

Inhaled corticosteroids vs placebo

Proportion with adverse effects of treatment · adults with subacute and chronic cough

Inhaled corticosteroids (ICS) showed no clear difference in proportion with adverse effects of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Inhaled corticosteroids for subacute and chronic cough in adults 2013 · Cochrane Headline outcomes only
OR 1.67 [0.92, 3.04]
4 studies · 381 participants
Moderate

Topical corticosteroids vs Another topical agent or placebo

Adverse effects of long‐term use of available topical agents · HIV‐infected adults (> 13 years of age, per CDC) with one or more painful intraoral aphthous ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
0 studies
No studies found

Standard treatment plus systemic corticosteroids vs usual care

Adverse effects: exposure keratopathy · patients age 10 years and older with periorbital or orbital cellulitis

It is very uncertain whether standard treatment plus systemic corticosteroids changes adverse effects: exposure keratopathy compared with standard treatment alone (very low certainty).

1 finding from 1 review

Corticosteroids for periorbital and orbital cellulitis 2021 · Cochrane Headline outcomes only
RR 1.2 [0.4, 3.63]
1 study · 21 participants
Very low

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

B4: Discontinuation of therapy due to maternal adverse effects – an all women · the woman

1 finding from 1 review

Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 485 participants
Low

Systemic interventions (aciclovir, thalidomide, corticosteroids, rebamipide, etanercept, colchicine, interferon-alpha) vs placebo

Safety of the intervention (adverse effects) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

1 finding from 1 review

Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
SoF 2 (systemic interventions vs placebo), grouped comment spanning all four listed outcomes (verbatim; the review's wording "topical" is a typo for systemic): "8 placebo-controlled trials evaluated topical…
Studies not reported
GRADE not reported