Antibiotics showed no clear difference in all adverse events compared with placebo or usual care (low certainty).
Antibiotics showed no clear difference in serious adverse events compared with placebo (low certainty).
Antibiotics showed no clear difference in adverse events ‐ diarrhoea compared with placebo overall (moderate certainty).
Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).
Antibiotics showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).
Antibiotics showed no clear difference in adverse events causing study drug discontinuation compared with placebo (low certainty).
Antibiotics showed no clear difference in serious adverse events Duration 3 days to 3 weeks compared with placebo or usual care (low certainty).
It is very uncertain whether oral antibiotics changes adverse events at 1 month compared with placebo (very low certainty).
Antibiotics showed no clear difference in adverse events ‐ overall (any adverse events not specified) compared with placebo overall (moderate certainty).
Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.
It is very uncertain whether antibiotics plus probiotics changes serious adverse events compared with placebo or no intervention (very low certainty).
It is very uncertain whether adverse events with anti‐gram‐positive antibiotics changes any adverse events compared with placebo (very low certainty).
It is very uncertain whether antibiotics plus probiotics changes withdrawals due to adverse events compared with placebo or no intervention (very low certainty).
It is very uncertain whether summary of findings table ‐ Antibiotics changes non‐serious adverse events compared with placebo or no intervention (very low certainty).
The review found no eligible studies for this question.
It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious compared with placebo or no intervention (very low certainty).
It is very uncertain whether scaling and root planing (SRP) plus antibiotics (amoxicillin and… changes adverse events due to periodontal therapy compared with supragingival scaling (plus placebo) (very low certainty).