Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

711 questions · 751 findings · 86 reviews

No studies found 171 · 22.8%GRADE not reported 61 · 8.1%Very low 192 · 25.6%Low 174 · 23.2%Moderate 108 · 14.4%High 45 · 6%

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Exacerbation frequency · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Adverse effects of treatment · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

Oral plus nebulised antibiotics showed no clear difference in adverse effects of treatment compared with oral antibiotics plus nebulised placebo (low certainty).

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Eradication of MRSA · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

Oral plus nebulised antibiotics showed no clear difference in eradication of MRSA compared with oral antibiotics plus nebulised placebo (low certainty).

1 finding from 1 review

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Time until next positive MRSA isolate (from clinically relevant respiratory culture) · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics at time of replacement vs no antibiotics at time of replacement

Adverse effects (Death) · adults with replacing long‐term indwelling urinary catheters

It is very uncertain whether antibiotics at time of replacement changes adverse effects (Death) compared with no antibiotics at time of replacement (very low certainty).

1 finding from 1 review

Antibiotics plus probiotics vs placebo or no intervention

Failure to induce clinical remission at end of study · people with active UC

It is very uncertain whether antibiotics plus probiotics changes failure to induce clinical remission at end of study compared with placebo or no intervention (very low certainty).

1 finding from 1 review