Question · asked by 1 review
Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo: Adverse effects of treatment
- Population
- adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract specimen
- Intervention
- Oral plus nebulised antibiotics
- Comparison
- oral antibiotics plus nebulised placebo
- Outcome
- Adverse effects of treatment
Oral plus nebulised antibiotics showed no clear difference in adverse effects of treatment compared with oral antibiotics plus nebulised placebo (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo Adverse effects of treatment · adults and children with cystic fibrosis and a positive microbiological isolate of MRSA from a respiratory tract… Oral plus nebulised antibiotics showed no clear difference in adverse effects of treatment compared with oral antibiotics plus nebulised placebo (low certainty). Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic… (2022) · Cochrane Headline outcomes only | OR 3 [0.11, 79.91] | 1 study · 29 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.