Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

888 questions · 936 findings · 109 reviews

No studies found 196 · 20.9%GRADE not reported 88 · 9.4%Very low 226 · 24.1%Low 217 · 23.2%Moderate 152 · 16.2%High 57 · 6.1%

Antibiotics (short duration) vs antibiotics (long duration) postpartum

Treatment failure (vaginal and cesarean delivery) · women with management of intra‐amniotic infection

Antibiotics (short duration) showed no clear difference in treatment failure (vaginal and cesarean delivery) compared with antibiotics (long duration) postpartum (low certainty).

1 finding from 1 review

Antibiotics vs placebo compared

Clinical cure · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze

Antibiotic therapy showed no clear difference in clinical cure (symptomatic and clinical recovery by the end of… compared with placebo compared to placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo compared

Treatment failure (development of more severe signs and symptoms by the end of treatment) · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze

Antibiotic therapy may leads to lower treatment failure (development of more severe signs and symptoms by… compared with placebo compared to placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo compared

Relapse · children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze

Antibiotic therapy showed no clear difference in relapse (children who were 'cured' but developed symptoms within… compared with placebo compared to placebo (low certainty).

1 finding from 1 review

14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen

Exacerbation frequency · people with bronchiectasis

14 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off antibiotic regimen (moderate certainty).

2 findings from 1 review