Cochrane · systematic review · CD009576
Antibiotic therapy versus no antibiotic therapy for children aged 2 to 59 months with WHO‐defined non‐severe pneumonia and wheeze
Lassi, ZS, Padhani, ZA, Das, JK, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Acute Respiratory InfectionsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 75%Moderate 1 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Antibiotic therapy versus placebo compared to placebo for children aged 2 to 59 months with WHO‐defined non‐severe pneumonia and wheeze
Population: children, aged 2 to 59 months, with WHO‐defined non‐severe pneumonia and wheeze
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical cure (symptomatic and clinical recovery by the end of treatment) Antibiotic therapy vs placebo compared to placebo | RR 1.02 [0.96, 1.08] | 1 study · 456 participants | Moderate Downgraded: imprecision |
Treatment failure (development of more severe signs and symptoms by the end of treatment) Antibiotic therapy vs placebo compared to placebo | RR 0.8 [0.68, 0.94] | 3 studies · 3222 participants | Low Downgraded: risk of bias, imprecision |
Relapse (children who were 'cured' but developed symptoms within 14‐day Antibiotic therapy vs placebo compared to placebo | RR 1 [0.74, 1.34] | 3 studies · 2795 participants | Low Downgraded: risk of bias, imprecision |
Treatment harms (adverse events or side effects associated with antibiotic therapy within 14‐day Antibiotic therapy vs placebo compared to placebo | RR 0.81 [0.6, 1.09] | 3 studies · 3253 participants | Low Downgraded: risk of bias, imprecision |