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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
434 questions in 75 reviews · Metabolic and Endocrine Disorders
current versionsNo studies 434 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise Cardiovascular mortality · people at increased risk for developing type 2 diabetes Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at… (2019) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise Non‐fatal myocardial infarction/stroke · people at increased risk for developing type 2 diabetes Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at… (2019) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise Health‐related quality of life · people at increased risk for developing type 2 diabetes Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at… (2019) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table for metformin vs diet and exercise or another antidiabetic drug Sulphonylurea · people at increased risk for developing type 2 diabetes Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at… (2019) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table for metformin vs diet and exercise or another antidiabetic drug Thiazolidinediones · people at increased risk for developing type 2 diabetes Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at… (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Health‐related quality of life Oxandrolone for growth hormone‐treated girls aged up to 18 years with Turner syndrome (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR All‐cause mortality Oxandrolone for growth hormone‐treated girls aged up to 18 years with Turner syndrome (2019) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fluoxetine vs placebo Health‐related quality of life · overweight or obese adults Fluoxetine for adults who are overweight or obese (2019) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fluoxetine vs placebo All‐cause mortality · overweight or obese adults Fluoxetine for adults who are overweight or obese (2019) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: fluoxetine vs placebo Socioeconomic effects · overweight or obese adults Fluoxetine for adults who are overweight or obese (2019) · Cochrane | no estimate extracted | NR | No studies |
Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug All‐cause mortality (N) Metformin and second‐ or third‐generation sulphonylurea combination therapy for adults with type 2 diabetes… (2019) · Cochrane | no estimate extracted | NR | No studies |
Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug Health‐related quality of life Metformin and second‐ or third‐generation sulphonylurea combination therapy for adults with type 2 diabetes… (2019) · Cochrane | no estimate extracted | NR | No studies |
Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug Non‐fatal stroke (N) Metformin and second‐ or third‐generation sulphonylurea combination therapy for adults with type 2 diabetes… (2019) · Cochrane | no estimate extracted | NR | No studies |
Intraoperative neuromonitoring vs visual nerve identification only during thyroidectomy Health‐related quality of life Intraoperative neuromonitoring versus visual nerve identification for prevention of recurrent laryngeal… (2019) · Cochrane | no estimate extracted | NR | No studies |
Intraoperative neuromonitoring vs visual nerve identification only during thyroidectomy Socioeconomic effects Intraoperative neuromonitoring versus visual nerve identification for prevention of recurrent laryngeal… (2019) · Cochrane | no estimate extracted | NR | No studies |
Sublingual glucose vs oral (swallowed) glucose Resolution of symptoms, time to resolution of symptoms · children with hypoglycaemia associated with moderate clinical symptoms of acute malaria or moderate respiratory tract… First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Buccal glucose vs oral (swallowed) glucose Resolution of hypoglycaemia · healthy volunteers (adults) First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Buccal glucose vs oral (swallowed) glucose Time to resolution of hypoglycaemia · healthy volunteers (adults) First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Buccal glucose vs oral (swallowed) glucose Adverse events · healthy volunteers (adults) First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Buccal glucose vs oral (swallowed) glucose Ease of administration/treatment delay · healthy volunteers (adults) First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose Time to resolution of symptoms · adult patients with insulin‐dependent diabetes First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose Resolution of hypoglycaemia · adult patients with insulin‐dependent diabetes First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose Time to resolution of hypoglycaemia · adult patients with insulin‐dependent diabetes First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose Adverse events · adult patients with insulin‐dependent diabetes First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral + buccal glucose (dextrose gel) vs oral (swallowed) glucose Ease of administration/treatment delay · adult patients with insulin‐dependent diabetes First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Sublingual glucose vs oral (swallowed) glucose Treatment delay · children with hypoglycaemia associated with moderate clinical symptoms of acute malaria or moderate respiratory tract… First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Buccal glucose vs oral (swallowed) glucose Resolution of symptoms, time to resolution of symptoms · healthy volunteers (adults) First aid glucose administration routes for symptomatic hypoglycaemia (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral vs intramuscular vitamin B12 Clinical signs and symptoms Oral vitamin B₁₂ versus intramuscular vitamin B₁₂ for vitamin B₁₂ deficiency (2018) · Cochrane | no estimate extracted | NR | No studies |
Oral vs intramuscular vitamin B12 Health‐related quality of life Oral vitamin B₁₂ versus intramuscular vitamin B₁₂ for vitamin B₁₂ deficiency (2018) · Cochrane | no estimate extracted | NR | No studies |
Oral vs intramuscular vitamin B12 Acceptability Oral vitamin B₁₂ versus intramuscular vitamin B₁₂ for vitamin B₁₂ deficiency (2018) · Cochrane | no estimate extracted | NR | No studies |
Acarbose vs no intervention Serious adverse events · people at risk of developing type 2 diabetes mellitus Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated… (2018) · Cochrane | no estimate extracted | NR | No studies |
Acarbose vs no intervention Health‐related quality of life · people at risk of developing type 2 diabetes mellitus Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated… (2018) · Cochrane | no estimate extracted | NR | No studies |
Acarbose vs no intervention Socioeconomic effects · people at risk of developing type 2 diabetes mellitus Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated… (2018) · Cochrane | no estimate extracted | NR | No studies |
Acarbose vs placebo Health‐related quality of life · people at risk of developing type 2 diabetes mellitus Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated… (2018) · Cochrane | no estimate extracted | NR | No studies |
Acarbose vs placebo Socioeconomic effects · people at risk of developing type 2 diabetes mellitus Alpha‐glucosidase inhibitors for prevention or delay of type 2 diabetes mellitus and its associated… (2018) · Cochrane | no estimate extracted | NR | No studies |
Sliding scale insulin vs basal‐bolus insulin Diabetes‐related morbidity · non‐critically ill hospitalised adults with diabetes mellitus Sliding scale insulin for non‐critically ill hospitalised adults with diabetes mellitus (2018) · Cochrane | no estimate extracted | NR | No studies |
Sliding scale insulin vs basal‐bolus insulin Socioeconomic effects · non‐critically ill hospitalised adults with diabetes mellitus Sliding scale insulin for non‐critically ill hospitalised adults with diabetes mellitus (2018) · Cochrane | no estimate extracted | NR | No studies |
Laparoscopic retroperitoneal adrenalectomy vs laparoscopic transperitoneal adrenalectomy Health‐related quality of life Transperitoneal versus retroperitoneal laparoscopic adrenalectomy for adrenal tumours in adults (2018) · Cochrane | no estimate extracted | NR | No studies |
Short‐acting insulin analogues vs regular human insulin Macrovascular or microvascular complications Short‐acting insulin analogues versus regular human insulin for adult, non‐pregnant persons with type 2… (2018) · Cochrane | no estimate extracted | NR | No studies |
Short‐acting insulin analogues vs regular human insulin Socioeconomic effects Short‐acting insulin analogues versus regular human insulin for adult, non‐pregnant persons with type 2… (2018) · Cochrane | no estimate extracted | NR | No studies |
Diet vs physical activity or standard treatment Non‐fatal myocardial infarction/stroke · people at increased risk of developing type 2 diabetes mellitus Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated… (2017) · Cochrane | no estimate extracted | NR | No studies |
Diet vs physical activity or standard treatment Health‐related quality of life · people at increased risk of developing type 2 diabetes mellitus Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated… (2017) · Cochrane | no estimate extracted | NR | No studies |
Diet vs physical activity or standard treatment Socioeconomic effects · people at increased risk of developing type 2 diabetes mellitus Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated… (2017) · Cochrane | no estimate extracted | NR | No studies |
Physical activity vs standard treatment Socioeconomic effects · people at increased risk of developing type 2 diabetes mellitus Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated… (2017) · Cochrane | no estimate extracted | NR | No studies |
Psychological interventions vs usual care Diabetes‐related complications Psychological interventions for diabetes‐related distress in adults with type 2 diabetes mellitus (2017) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Socioeconomic effects · people at risk for development of T2DM Dipeptidyl‐peptidase (DPP)‐4 inhibitors and glucagon‐like peptide (GLP)‐1 analogues for prevention or delay… (2017) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Health‐related quality of life · people at risk for development of T2DM Dipeptidyl‐peptidase (DPP)‐4 inhibitors and glucagon‐like peptide (GLP)‐1 analogues for prevention or delay… (2017) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Socioeconomic effects · people at risk for development of T2DM Dipeptidyl‐peptidase (DPP)‐4 inhibitors and glucagon‐like peptide (GLP)‐1 analogues for prevention or delay… (2017) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR All‐cause mortality · children (aged 6 to 11 years) being overweight or obese Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from… (2017) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Morbidity · children (aged 6 to 11 years) being overweight or obese Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from… (2017) · Cochrane | no estimate extracted | NR | No studies |