Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

15,213 questions in 2,394 reviews

current versions
No studies 15,213 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Intervention NR
Cluster‐RCTs · adults and children
Interventions to improve sanitation for preventing diarrhoea (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Cluster‐RCTs · adults and children
Interventions to improve sanitation for preventing diarrhoea (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
NRCTs · adults and children
Interventions to improve sanitation for preventing diarrhoea (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Cluster‐RCTs · adults and children
Interventions to improve sanitation for preventing diarrhoea (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Non‐randomized studies** · adults and children
Interventions to improve sanitation for preventing diarrhoea (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Non‐randomized studies** · adults and children
Interventions to improve sanitation for preventing diarrhoea (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Cluster‐RCTs · adults and children
Interventions to improve sanitation for preventing diarrhoea (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Non‐randomized studies** · adults and children
Interventions to improve sanitation for preventing diarrhoea (2023) · Cochrane
no estimate extractedNRNo studies
Pharmacologic intervention vs another pharmacologic intervention
Harmful alcohol use ‐ not measured · individuals with alcohol use disorder
Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low‐ and middle‐income countries (2023) · Cochrane
no estimate extractedNRNo studies
Pharmacologic intervention vs another pharmacologic intervention
Harmful alcohol use ‐ not measured · individuals with alcohol use disorder
Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low‐ and middle‐income countries (2023) · Cochrane
no estimate extractedNRNo studies
Percutaneous nephrolithotomy vs retrograde intrarenal surgery
Unplanned medical visits Assumed MCID: 5% · adults with renal stones
Percutaneous nephrolithotomy versus retrograde intrarenal surgery for treatment of renal stones in adults (2023) · Cochrane
no estimate extractedNRNo studies
Percutaneous nephrolithotomy vs retrograde intrarenal surgery
Quality of life Assumed MCID: NA · adults with renal stones
Percutaneous nephrolithotomy versus retrograde intrarenal surgery for treatment of renal stones in adults (2023) · Cochrane
no estimate extractedNRNo studies
Exercise intervention vs no exercise intervention
Overall survival · adults with breast or prostate cancer receiving radiation therapy alone
Exercise interventions for adults with cancer receiving radiation therapy alone (2023) · Cochrane
no estimate extractedNRNo studies
Exercise intervention vs no exercise intervention
Return to work · adults with breast or prostate cancer receiving radiation therapy alone
Exercise interventions for adults with cancer receiving radiation therapy alone (2023) · Cochrane
no estimate extractedNRNo studies
Topical tranexamic acid vs placebo
Re‐operation due to bleeding (7 days post‐surgery) ‐ not reported · people undergoing definitive fixation of hip, pelvic and long bone fractures
Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or… (2023) · Cochrane
no estimate extractedNRNo studies
Topical tranexamic acid vs placebo
Risk of suspected serious drug reactions (30 days) ‐ not reported · people undergoing definitive fixation of hip, pelvic and long bone fractures
Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or… (2023) · Cochrane
no estimate extractedNRNo studies
Intravenous tranexamic acid vs placebo
Re‐operation due to bleeding (7 days post‐surgery) ‐ not reported · people undergoing definitive fixation of hip, pelvic and long bone fractures
Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Depression none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Anxiety none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Quality of life none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Pain intensity none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Disability none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Depression none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Anxiety none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Quality of life none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Depression none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Anxiety none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Pain intensity none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Disability none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Adverse events none of the studies reported on this outcome · children and adolescents aged 4 years to 18 years, with chronic musculoskeletal pain
Physical activity and education about physical activity for chronic musculoskeletal pain in children and… (2023) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Outcomes  · adults with compensated or decompensated advanced chronic liver disease
Granulocyte colony‐stimulating factor with or without stem or progenitor cell or growth factors infusion for… (2023) · Cochrane
no estimate extractedNRNo studies
Oxygenation vs no oxygenation during the apnoeic period preceding intubation
Hospital stay · people requiring tracheal intubation
Oxygenation during the apnoeic phase preceding intubation in adults in prehospital, emergency department,… (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings 1. Amorphous hydrogel dressings vs other types of dressings
Time to complete wound healing (re‐epithelialisation) (days) Measured using photographs · children with skin graft donor sites
Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings 2. Octenidine‐dihydrochloride (OCT) hydrogel dressings vs OCT‐free placebo hydrogel dressings
Donor site pain · adults with skin graft donor sites
Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings 2. Octenidine‐dihydrochloride (OCT) hydrogel dressings vs OCT‐free placebo hydrogel dressings
Health‐related quality of life · adults with skin graft donor sites
Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings 2. Octenidine‐dihydrochloride (OCT) hydrogel dressings vs OCT‐free placebo hydrogel dressings
Wound complications · adults with skin graft donor sites
Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings 1. Amorphous hydrogel dressings vs other types of dressings
Health‐related quality of life · children with skin graft donor sites
Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane
no estimate extractedNRNo studies
Summary of findings 1. Amorphous hydrogel dressings vs other types of dressings
Wound infection · children with skin graft donor sites
Hydrogel dressings for donor sites of split‐thickness skin grafts (2023) · Cochrane
no estimate extractedNRNo studies
Antiplatelet agent vs placebo
Outcomes (measurement) · asymptomatic carotid stenosis
Pharmacological interventions for asymptomatic carotid stenosis (2023) · Cochrane
no estimate extractedNRNo studies
Antihypertensive agent vs placebo
Neurological impairment · asymptomatic carotid stenosis
Pharmacological interventions for asymptomatic carotid stenosis (2023) · Cochrane
no estimate extractedNRNo studies
Antihypertensive agent vs placebo
Major bleeding · asymptomatic carotid stenosis
Pharmacological interventions for asymptomatic carotid stenosis (2023) · Cochrane
no estimate extractedNRNo studies
Antihypertensive agent vs placebo
Adverse events · asymptomatic carotid stenosis
Pharmacological interventions for asymptomatic carotid stenosis (2023) · Cochrane
no estimate extractedNRNo studies
Antihypertensive agent vs placebo
Quality of life · asymptomatic carotid stenosis
Pharmacological interventions for asymptomatic carotid stenosis (2023) · Cochrane
no estimate extractedNRNo studies
Anticoagulant agent vs placebo
Outcomes (measurement/time point) · asymptomatic carotid stenosis
Pharmacological interventions for asymptomatic carotid stenosis (2023) · Cochrane
no estimate extractedNRNo studies
Anticoagulant agent vs placebo
Neurological impairment · asymptomatic carotid stenosis
Pharmacological interventions for asymptomatic carotid stenosis (2023) · Cochrane
no estimate extractedNRNo studies
Anticoagulant agent vs placebo
Ipsilateral major or disabling stroke · asymptomatic carotid stenosis
Pharmacological interventions for asymptomatic carotid stenosis (2023) · Cochrane
no estimate extractedNRNo studies
Antiplatelet agent vs placebo
Neurological impairment · asymptomatic carotid stenosis
Pharmacological interventions for asymptomatic carotid stenosis (2023) · Cochrane
no estimate extractedNRNo studies
Anticoagulant agent vs placebo
Stroke‐related mortality · asymptomatic carotid stenosis
Pharmacological interventions for asymptomatic carotid stenosis (2023) · Cochrane
no estimate extractedNRNo studies