What do systematic reviews say?

Proportion of participants with ≥ 1 serious adverse events · people with acute subarachnoid haemorrhage

Proportion of participants with ≥ 1 serious adverse events · chronic hepatitis B

Proportion of participants with ≥ 1 serious adverse events · chronic hepatitis B

Mortality or serious adverse events requiring hospital admission · Adults or children at increased risk of bacterial endocarditis (pre-existing cardiac condition) undergoing an invasive dental procedure

Number of participants experiencing any serious adverse events · patients with osteoarthritis

Number of participants experiencing any serious adverse events · patients with osteoarthritis

Serious adverse events/death: long‐term outcomes ‐ not reported · rehabilitation (long‐term outcomes)

Adverse events Participants (n) reported serious adverse events · patients with treating osteoarthritis

Adverse events Participants (n) reported serious adverse events · patients with treating osteoarthritis

Adverse events Participants (n) reported serious adverse events · patients with osteoarthritis of the knee

Adverse events Participants (n) reported serious adverse events · patients with osteoarthritis of the knee

Adverse events Participants (n) reported serious adverse events · patients with hand osteoarthritis

Proportion of participants with 1 or more serious adverse events · chronic hepatitis B

Serious adverse events or complications of treatment — not reported

Proportion of people with ≥ 1 serious adverse events during treatment · participants with unresectable hepatocellular carcinoma

Proportion of people with ≥ 1 serious adverse events during treatment · participants with unresectable hepatocellular carcinoma

Proportion of participants with ≥ 1 serious adverse events ‐ not reported · adults with biliary sphincter of Oddi dysfunction

Non‐serious adverse events Timing of outcome assessment: end of treatment · patients with borderline personality disorder

Proportion of participants with ≥ 1 non‐serious adverse events ‐ not reported · adults with biliary sphincter of Oddi dysfunction

Proportion of participants with ≥ 1 non‐serious adverse events ‐ not reported · adults with biliary sphincter of Oddi dysfunction