Discomfort associated with the procedure · People with dental caries in primary teeth (mainly children)
The reported estimate for discomfort with ART versus conventional treatment was inconclusive (ungraded).
1 finding from 1 review
Dental caries · Children and adolescents (general population, aged under 20 years)
Across two studies, 50% showed any association of potential public health harm for dental caries (very low certainty).
1 finding from 1 review
Post-Streptococcus mutans prediction accuracy · Dental images of human beings
The review reported 99% accuracy for post-Streptococcus mutans prediction in Javed et al. (Ungraded).
1 finding from 1 review
Choking · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
No significant difference in choking risk was found between BLW/BLISS-fed and traditionally fed infants (ungraded).
1 finding from 1 review
Body weight / BMI · Children and adolescents (general population, aged under 20 years)
Evidence on food marketing and body weight is very uncertain (very low certainty); a single study found no association.
1 finding from 1 review
Beta diversity and community composition · Participants in oral 16S rRNA caries microbiome studies
Beta-diversity matrices showed statistically significant ADONIS results, while clustering by study and 16S region was also observed; no pooled effect estimate was reported.
1 finding from 1 review
Lightness/brightness change of white spot lesion (luminosity L*, T0 to T1) · Patients with post-orthodontic white spot lesions and permanent dentition
ICON resin infiltration showed no statistically significant change in lightness/brightness of post-orthodontic white spot lesions at 6 months (pooled Cohen's d/SMD -0.001, 95% CI -0.23 to 0.23; 3 studies, 330 teeth; I2=97%); not GRADE-rated.
1 finding from 1 review
Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No eligible studies compared oral hairy leukoplakia between different ART regimens.
1 finding from 1 review
Dental caries prevalence · European adolescents aged 18 years
Pooled caries prevalence was 0.94 (I² = 0%).
1 finding from 1 review
Mucosal hyperpigmentation prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in mucosal hyperpigmentation between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 1.79 [0.89, 3.61]
Studies not reported
Very low
Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis and closed (mature) root apex due to carious pulp exposure
In closed-apex teeth, pooled pulpotomy success was 83% (95% CI 69-91%); significantly lower than open apex (z=2.33, p=0.02); ungraded.
1 finding from 1 review
Caries experience · Children (mean age newborn to ~5.2 years) and their parents/carers
Comprehensive interventions produced a statistically significant reduction in tooth-level caries (dmft SMD -0.47, 95% CI -0.84 to -0.10; 4 studies; not GRADE-rated), though heterogeneity was very high.
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; no bevel had twice the failure rate in the review narrative.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R14 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R14 was significantly associated with ECC in the TWAS (p = 1.06e-6); genetic association, ungraded.
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; the review reports this three-arm comparison but tabulates only compomer failure.
1 finding from 1 review
Secondary/higher maternal education prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries
About 45% of children with caries in LMICs had mothers with secondary or higher education (pooled prevalence 0.450, 95% CI 0.330 to 0.572; 7 studies; not GRADE-rated).
1 finding from 1 review
Intervention not reported
Caries experience - mean dmfs (descriptive), primary dentition
1 finding from 1 review
Intervention not reported
Difference in summary sensitivity (NMA, Analysis 2)
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
SDF had no significant effect on oral health-related quality of life versus pooled standard-of-care caries treatments (SMD -0.06, 95% CI -0.20 to 0.08; ungraded).
1 finding from 1 review
Dental caries · Children (deciduous and/or permanent dentition) in low- and middle-income countries
Caregiver help with tooth brushing was associated with 65% lower odds of dental caries (OR 0.35, 95% CI 0.13 to 0.93; 3 studies; very high heterogeneity; not GRADE-rated).
1 finding from 1 review