Side effects or other adverse events · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment
1 finding from 1 review
Secondary caries prevention in young permanent first molars · Children with deep occlusal caries in young permanent first molars (indirect pulp capping)
SDF+KI and RMGIC did not differ significantly for secondary caries prevention (p>0.05; ungraded).
1 finding from 1 review
MMP-9 location/depth · Human carious dentin
Opposite effect directions were reported for MMP-9 by lesion depth or location (very low certainty).
1 finding from 1 review
no estimate extracted
3 studies
Very low
Poor oral health-related quality of life (OHRQoL) · Indians
Results were inconsistent and certainty was very low.
1 finding from 1 review
Change in height-for-age z score · Children aged ≤6 years (early childhood)
The association between baseline caries and declining height-for-age persisted after adjustment (coefficient -0.02); ungraded.
1 finding from 1 review
Knowledge, attitudes and perceptions of staff and patients regarding oral health · People of all ages and abilities served through primary care and related settings (children, pregnant women, older adults in…
Integration strategies were generally associated with positive oral health knowledge, attitudes and perceptions among staff and patients (16 studies, narrative synthesis; ungraded).
1 finding from 1 review
Plaque · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
CPC mouthwash may reduce plaque-related indexes versus blank control in the short term, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
Caries arrest · Patients with early enamel carious lesions on permanent molars
SDF plus potassium iodide arrested 54.8% of early enamel lesions at 24 months; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · People or specimens with white spot lesions or early caries lesions
The NMA estimated an SMD of -0.78 for P11-4 + fluoride varnish versus CPP-ACP (95% CI -1.33 to -0.28).
1 finding from 1 review
SMD -0.78 [-1.33, -0.24]
Studies not reported
GRADE not reported
new carious lesions or fillings · Children with dental caries in permanent (first) molars
SDF had a 57% preventative fraction; the comparator was not reported.
1 finding from 1 review
Locoregional recurrence · Adults with oral cavity or oropharyngeal cancer
Sentinel node biopsy (neck dissection only if biopsy positive) showed no clear difference in locoregional recurrence compared with elective neck dissection (low certainty).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Self-assembling peptide P11-4 significantly improved remineralization versus control (SMD -0.56, 95% CI -0.96 to -0.15); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; deciduous (primary) teeth
Over 2 or more years in deciduous teeth, secondary caries did not differ significantly between compomer and RMGIC (RR 1.68, 95% CI 0.87-3.25; low certainty).
1 finding from 1 review
Periodontal health during molar intrusion · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment
1 finding from 1 review
Abellan 2021 assessed periodontal health (plaque index, pocket depth, bleeding on probing) after intrusion of maxillary molars; no evidence of significant difference with LLLT. Statistical test results not published.
1 study
GRADE not reported
Survival of retainers (failure, lower arch) · People who had received fixed appliance orthodontic treatment
Fibre-reinforced composite fixed (bonded) retainer showed no clear difference in survival of retainers (failure, lower arch) compared with multistrand / spiral wire fixed (bonded) retainer (low certainty).
1 finding from 1 review
Recurrence · Adults with oral cavity or oropharyngeal cancer with nodal disease (stage N2 or N3)
1 finding from 1 review
Total number of orthodontic appliance adjustment appointments during alignment stage · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment
It is very uncertain whether low level laser therapy (LLLT) changes total number of orthodontic appliance adjustment appointments during… compared with conventional orthodontic appliance treatment (very low certainty).
1 finding from 1 review
Cariogenic bacteria (Mutans streptococci) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Herbal mouthwash reduced Mutans streptococci versus placebo, but certainty is very low.
1 finding from 1 review
Survival of retainers (failure, lower arch) · People who had received fixed appliance orthodontic treatment
It is very uncertain whether part-time clear plastic (removable) retainer changes survival of retainers (failure, lower arch) compared with any type of fixed (bonded) retainer (very low certainty).
1 finding from 1 review
Remineralization/arrest of early enamel carious lesions · Patients with early enamel carious lesions on permanent molars
For early enamel lesions, annual SDF+KI was significantly LESS effective than twice-daily tricalcium silicate paste (54.8% vs 100% arrested; p<0.001; ungraded).
1 finding from 1 review