Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported that tooth loss and edentulism negatively affect oral health-related quality of life.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Oral health-related quality of life · Adolescents (10-19 years)
Malocclusion is associated with worse oral health-related quality of life in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
MMP-2 expression/activity · Human carious dentin
No difference in MMP-2 expression/activity was found before versus after cavity sealing (very low certainty).
1 finding from 1 review
Mean weight‐for‐age z‐score · Children aged 1–6 years
The review reported lower weight-for-age z scores in children with pulp-involved caries.
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; deciduous (primary) teeth
In deciduous teeth at 1 year, a single small trial found no difference in secondary caries between RMGIC and resin composite (RR 1.03, 95% CI 0.07-15.81; ungraded).
1 finding from 1 review
MMP-13 presence/activity · Human ex vivo carious dentin
MMP-13 may be increased in root compared with coronal carious dentin, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
Future caries experience (dmft/dmfs) · Children younger than 6 years with caries-free primary dentition (no cavitated or non-cavitated lesions at baseline)
Children with mutans streptococci at baseline had a greater future caries experience (SMD 0.85, a large effect; ungraded).
1 finding from 1 review
Continued root formation / root development · Patients with carious pulp exposure in permanent teeth (predominantly immature) undergoing DPC or pulpotomy
Evidence on continued root formation for calcium hydroxide versus MTA is weak and inconclusive (3 RCTs, not pooled; ungraded).
1 finding from 1 review
Cathepsin B (CT-B) presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
Cathepsin B may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
CT-B may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain (Vidal et al., 2014; Nascimento et al., 2011: significantly higher in caries, p<0.05).
2 studies · 22 participants
Very low
new carious lesions or fillings at fissure-site level · children with caries in permanent molars
SDF had a 52% preventative fraction at fissure-site level; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Recurrence · Adults with oral cavity or oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review
Disease-free survival · Adults with oropharyngeal cancer
Surgery showed no clear difference in disease-free survival (new disease, progression, and mortality) compared with radiotherapy alone (low certainty).
1 finding from 1 review
MMP-13 activity · Human root and coronal carious dentin
MMP-13 may be increased in root compared with coronal carious dentin (very low certainty).
1 finding from 1 review
no estimate extracted
1 study · 7 participants
Very low
Predictive performance for coronal caries increment (positive likelihood ratio, LR+) · Children and adolescents (aged 2-19) at risk of coronal caries increment (caries onset or progression)
Most externally validated coronal-caries models showed modest LR+ (<5); only Campus 2012 and Gao 2013 NUS-CRA reached the useful threshold; no pooled estimate; ungraded.
2 findings from 1 review
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up >=1 year (included studies 1-5 years) · Oral health care; children/adolescents; no geographical restriction · Model validation studies
No meta-analysis. Per-model LR+ (Table 2) across the 9 validation studies (31 coronal models) ranged roughly 0.78-5.53 (e.g. Beck 1.62-3.00, Christian/CAMBRA 1.09-1.14, Gao 2013 CAT ~1.03 to NUS-CRA 5.31, Campus 5.53,…
9 studies
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up >=1 year (included studies 1-5 years) · Oral health care; children/adolescents; no geographical restriction (11 countries across all studies) · Model development studies
No meta-analysis (heterogeneity precluded pooling); performance given per model as LR+ recalculated by the review authors (Table 2). Across the 8 development studies (23 coronal models) LR+ spanned roughly 1.31-10.26…
8 studies
GRADE not reported
Oral health-related quality of life · Adolescents (10-19 years)
Being an only child and growing up in a nuclear family are associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomesCommunity/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
Being an only child, growing up in your nuclear family or family structure, household conditions, and number of people per household and maternal age are predictors of better OHRQoL [43].
Studies not reported
GRADE not reported
MMP-8 location/presence · Human carious dentin
Evidence on MMP-8 by lesion depth or location was very low certainty.
1 finding from 1 review
Recurrence · Adults with oropharyngeal cancer
The review found no eligible studies for this question.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth with mixed root development
The effect of MTA versus CH in teeth with mixed root development is very uncertain (very low certainty).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
P11-4 plus fluoride varnish did not differ significantly from P11-4 alone (SMD -0.40, 95% CI -0.97 to 0.17; indirect evidence only); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
White spot lesion clinical score (mean values), subject level · Healthy adolescents and adults undergoing orthodontic treatment with fixed multi-bracket appliances
In a pooled analysis of two placebo-controlled trials, fluoride varnish also reduced white spot lesion clinical scores (pooled SMD -0.44, 95% CI -0.64 to -0.24); this secondary outcome was not separately GRADE-rated.
1 finding from 1 review