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Evidence found and GRADE certainty

266 questions · 274 findings · 25 reviews · Movement Disorders

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No studies found 13 · 4.7%GRADE not reported 7 · 2.6%Very low 66 · 24.1%Low 66 · 24.1%Moderate 87 · 31.8%High 35 · 12.8%

Intervention not reported

Study withdrawal ( · people with essential tremor

The intervention may leads to higher study withdrawal ( (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events ( · people with essential tremor
1 finding from 1 review

Zonisamide vs placebo

Functional abilities Change in TRS part B score (motor tasks) Change in TRS part C score (functional disability) (higher scores indicate a better outcome) · patients with essential tremor

It is very uncertain whether zonisamide changes functional abilities Change in TRS part B score (motor tasks) Change… compared with placebo (very low certainty).

1 finding from 1 review

Zonisamide vs placebo

Study Withdrawals · patients with essential tremor

It is very uncertain whether zonisamide changes study withdrawal for any reason Number of participants withdrawn… compared with placebo (very low certainty).

1 finding from 1 review

Zonisamide vs placebo

Adverse events Number of adverse events · patients with essential tremor

It is very uncertain whether zonisamide changes adverse events Number of adverse events compared with placebo (very low certainty).

1 finding from 1 review

Botulinum toxin type A vs botulinum toxin type B

Adverse events: sore throat/dry mouth № of participants: 212 (2 RCTs) · adults with cervical dystonia

Botulinum toxin type A probably leads to higher adverse events: sore throat/dry mouth № of participants: 212 (2 RCTs) compared with botulinum toxin type B (moderate certainty).

1 finding from 1 review

Botulinum neurotoxin B vs placebo

Withdrawals due to adverse events · adults with cervical dystonia

Botulinum neurotoxin B showed no clear difference in proportion of withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Botulinum neurotoxin B vs placebo

Proportion of participants with adverse events · adults with cervical dystonia

It is very uncertain whether botulinum neurotoxin B changes proportion of participants with adverse events compared with placebo (very low certainty).

1 finding from 1 review