Cochrane · systematic review · CD004314
Botulinum toxin type A versus botulinum toxin type B for cervical dystonia
Duarte, GS, Castelão, M, Rodrigues, FB, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Movement DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Botulinum toxin type A versus botulinum toxin type B for adults with cervical dystonia
Population: adults with cervical dystonia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall cervical dystonia improvement: change from baseline to week 4 Botulinum toxin type A vs botulinum toxin type B | no estimate extracted | NR | Low Downgraded: imprecision |
Participants with adverse events № of participants: 111 (1 RCT) Botulinum toxin type A vs botulinum toxin type B | RR 1.4 [1, 1.96] | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Subjective change as assessed by the patient at week 4 Botulinum toxin type A vs botulinum toxin type B | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Cervical dystonia associated pain: change from baseline to week 2‐4 Botulinum toxin type A vs botulinum toxin type B | no estimate extracted | NR | Low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events: sore throat/dry mouth № of participants: 212 (2 RCTs) Botulinum toxin type A vs botulinum toxin type B | RR 4.39 [2.43, 7.91] | NR | Moderate Downgraded: risk of bias, imprecision, inconsistency |
Adverse events: dysphagia № of participants: 249 (3 RCTs) Botulinum toxin type A vs botulinum toxin type B | RR 2.89 [0.8, 10.41] | NR | Low Downgraded: risk of bias, imprecision, inconsistency |