Cochrane · systematic review · CD004315
Botulinum toxin type B for cervical dystonia
Marques, RE, Duarte, GS, Rodrigues, FB, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Movement DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 2 · 28.6%Moderate 1 · 14.3%High 3 · 42.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Botulinum neurotoxin B compared to placebo for cervical dystonia
Population: adults with cervical dystonia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall cervical dystonia improvement as Botulinum neurotoxin B vs placebo | no estimate extracted | 3 studies · 316 participants | Moderate Downgraded: risk of bias |
Proportion of withdrawals due to adverse events Botulinum neurotoxin B vs placebo | RR 0.88 [0.19, 4.06] | 4 studies · 440 participants | Low Downgraded: risk of bias, imprecision |
Cervical dystonia associated pain: change from baseline to week 4 as Botulinum neurotoxin B vs placebo | no estimate extracted | 2 studies · 207 participants | Low Downgraded: risk of bias, imprecision |
Subjective change as assessed by the patient at week 4 Botulinum neurotoxin B vs placebo | no estimate extracted | 3 studies · 316 participants | High |
Proportion of participants with adverse events Botulinum neurotoxin B vs placebo | RR 1.09 [0.97, 1.23] | 2 studies · 186 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events: dry mouth Botulinum neurotoxin B vs placebo | RR 7.65 [2.75, 21.32] | 4 studies · 438 participants | High |
Adverse events: dysphagia Botulinum neurotoxin B vs placebo | RR 6.78 [2.42, 19.05] | 4 studies · 438 participants | High |