Cochrane · systematic review · CD006941
Opioids for restless legs syndrome
de Oliveira, CO, Carvalho, LBC, Carlos, K, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Movement DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 100%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Opioids compared to placebo for RLS
Population: RLS
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
RLS symptoms Opioids vs placebo | no estimate extracted | 1 study · 270 participants | Low Downgraded: risk of bias |
RLS symptoms Opioids vs placebo | no estimate extracted | 1 study · 276 participants | Low Downgraded: risk of bias |
Drug responders Opioids vs placebo | RR 1.82 [1.37, 2.42] | 1 study · 276 participants | Low Downgraded: risk of bias |
Drug responders Opioids vs placebo | RR 1.92 [1.49, 2.48] | 1 study · 276 participants | Low Downgraded: risk of bias |
Remitters Opioids vs placebo | RR 2.14 [1.45, 3.16] | 1 study · 276 participants | Low Downgraded: risk of bias |
Adverse Events Opioids vs placebo | RR 1.22 [1.07, 1.39] | 1 study · 304 participants | Low Downgraded: risk of bias |
Quality of life Opioids vs placebo | no estimate extracted | 1 study · 276 participants | Low Downgraded: risk of bias |