Biofilm formation · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; ten included studies reported reduced or inhibited Streptococcus mutans biofilm formation with cranberry extract or fractions.
1 finding from 1 review
no estimate extracted
10 studies
GRADE not reported
Dental caries in permanent teeth · Nigerian individuals with permanent dentition (approximately 12 years and older)
In permanent dentition, high-frequency sugar consumption was associated with non-significant 15% higher odds of caries (OR 1.15, 95% CI 0.88 to 1.52), with no heterogeneity (I2=0%; ungraded).
1 finding from 1 review
Proportion of teeth with non-carious cervical lesions (NCCLs) in ancient skulls · Ancient/prehistoric human skulls (excavated/archaeological skeletal remains)
Non-carious cervical lesions affected a pooled proportion of about 0.4% of teeth in ancient skulls (4 studies; ungraded, very high heterogeneity I2=97.6%).
1 finding from 1 review
Dental caries prevalence · Brazilian children/adolescents in permanent dentition (BMI classified by CDC 2000 growth charts)
Overweight may make little or no difference to the odds of caries in the permanent dentition (very low certainty).
1 finding from 1 review
Determinants of oral diseases · Adult residents of slums and non-slum urban settings of LMICs
Age, education, income, oral-hygiene behaviour, dental-visit pattern and slum/disadvantaged residence are associated with oral disease; gender effects are disease-specific; ungraded.
1 finding from 1 review
Fourteen studies reported determinants: older age, less education, lower income, poor oral hygiene behaviour (brushing frequency, technique), infrequent dental visits and disadvantaged/slum residential setting were…
14 studies
GRADE not reported
Intra-examiner reliability · Children and adults with primary or permanent dentition
Intra-examiner kappa statistics ranged from 0.52 to 1.00 across 6 studies; no meta-analysis or GRADE rating was reported.
1 finding from 1 review
no estimate extracted
6 studies
GRADE not reported
Cell damage or cytotoxicity · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; one included study reported very low cell damage with grape seed extract.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Inter-examiner reliability · Children and adults with primary or permanent dentition undergoing dental caries assessment
Inter-examiner reliability ranged from kappa 0.44 to 0.91 across 13 studies (moderate to almost perfect agreement); certainty not graded.
1 finding from 1 review
Change in Mutans streptococci (MS) count in dental plaque · healthy people
Xylitol reduced Mutans streptococci in dental plaque more than sorbitol (SMD -0.45, 95% CI -0.69 to -0.21; 4 trials, I2=7%); not GRADE-rated.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure
MTA and Biodentine have similar pulpotomy success (OR 0.89, not significant; low certainty).
1 finding from 1 review
White spot lesion formation (QLF: fluorescence loss, lesion area) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Indirect bonding with a flowable adhesive favored less QLF-measured demineralization, with certainty not graded.
1 finding from 1 review
The DB group exhibited significantly higher loss of fluorescence and degree of demineralization compared to the IB group between T0 and T1, with notable differences in specific quadrants (p <0.05 for ΔF and ΔF max).
1 study · 51 participants
GRADE not reported
Dental caries · Children (<18 years) with vs without dental caries
TaqI/BglI(rs739837) over-dominant model: TT+GG vs TG was not significantly associated with dental caries (OR 0.89); ungraded.
1 finding from 1 review
Antioxidant capacity · Streptococcus mutans (in vitro cultures and biofilms)
One study reported antioxidant activity of cranberry polyphenol fractions (ungraded).
1 finding from 1 review
Caries arrestment at the surface level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
SDF probably makes little to no difference to surface-level caries arrestment versus other methods (moderate certainty).
1 finding from 1 review
Dental caries susceptibility · Institutionalized orphan children (roughly 3 to 18 years)
Primary teeth may carry a higher caries risk than permanent teeth in institutionalized children (RR 1.31), but the difference is not statistically significant (very low certainty).
1 finding from 1 review
Caries arrest · Children and adults (with or without carious lesions)
The review found no eligible studies for this question.
3 findings from 1 review
No studies reported data in this dentition type
0 studies
No studies found
No studies reported data in this dentition type
0 studies
No studies found
MD -0.13 [-0.87, 0.61]
1 study · 309 participants
Very low
Dental caries prevalence · Brazilian children under 5 years in primary dentition (BMI classified by WHO 2006 Z-score)
The evidence is very uncertain about the effect of overweight/obesity on caries odds in the primary dentition (WHO 2006 Z-score; very low certainty).
1 finding from 1 review
OR 0.86 [0.60, 1.22]
3 studies
Very low
Dental caries - SNP-based heritability · Japanese adults (present-study cohort)
SNP-based heritability of dental caries was low (h2=0.0258, SE 0.0155); ungraded.
1 finding from 1 review
Intervention not reported
Overall success (composite of clinical and radiographic success)
1 finding from 1 review
Caries arrestment at the tooth level · Children and adults without systemic diseases affecting dental health
SDF showed a higher caries-free proportion at the tooth level, but the reported difference was not statistically significant.
1 finding from 1 review