Question · asked by 1 review
Genome-wide common variants (aggregate additive; LD score regression) vs Not applicable (variance-component estimate): Dental caries - SNP-based heritability
- Population
- Japanese adults (present-study cohort)
- Intervention
- Genome-wide common variants (aggregate additive; LD score regression)
- Comparison
- Not applicable (variance-component estimate)
- Outcome
- Dental caries - SNP-based heritability
SNP-based heritability of dental caries was low (h2=0.0258, SE 0.0155); ungraded.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Genome-wide common variants (aggregate additive; LD score regression) vs Not applicable (variance-component estimate) Dental caries - SNP-based heritability · Japanese adults (present-study cohort) · Lifelong (germline genotype), Population-based genetic association study (Japanese direct-to-consumer genetic testing cohort), LDSC heritability (present study) SNP-based heritability of dental caries was low (h2=0.0258, SE 0.0155); ungraded. Genome-wide association meta-analysis identifies two novel loci associated with dental caries. (2024) All outcomes | h2 (observed-scale SNP heritability) 0.0258 | 1 study · 45525 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomes | Not applicable (primary GWAS with meta-analysis of one previously published GWAS; no systematic literature search) | 1 | Not applicable |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.