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Evidence found and GRADE certainty

4,317 questions · 75,239 findings · 5,342 reviews

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No studies found 15,213 · 20.2%GRADE not reported 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

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Occlusal splint vs Another occlusal splint with a different mechanism of action

Frequency of joint noise · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes frequency of joint noise compared with another occlusal splint with a different mechanism of action (very low certainty).

1 finding from 1 review

Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics

Pain at 48 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)

Postoperative systemic antibiotics… showed no clear difference in pain at 48 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Severity of joint noise · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes severity of joint noise compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).

1 finding from 1 review

Facemask with rapid maxillary expansion (RME) vs Pushing Splints

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask with rapid maxillary expansion (RME) showed no clear difference in wits appraisal compared with pushing Splints; GRADE not reported.

1 finding from 1 review

AA genotype vs AG+GG genotypes

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) recessive model: AA vs AG+GG was not significantly associated with dental caries (OR 1.09); ungraded.

1 finding from 1 review

NiTi arch wire of one cross-sectional size vs NiTi arch wire of a different cross-sectional size

Pain · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
1 finding from 1 review
  • Initial arch wires used in orthodontic treatment with fixed appliances 2024 · Cochrane All outcomes
    7 days
    Different sizes of NiTi wires (Alhaija 2021; Erdinc 2004); not pooled due to clinical heterogeneity; little or no difference at day 1. Erdinc 0.014 vs 0.016 inch higher pain at day 4 MD 5.00 (0.19 to 9.81) and day 6 MD…
    2 studies · 149 participants
    Low

Teledentistry diagnosis using DSLR or smartphone extra-oral photographs vs Visual or clinical examination

Negative predictive value for dental caries diagnosis · Children and adults with primary or permanent dentition

Negative predictive values were reported in 10 of the 13 studies that reported sensitivity and specificity; no meta-analysis or GRADE rating was reported.

1 finding from 1 review

Oral cancer patients (cases) vs Healthy controls

Alveolar bone loss · Adults in case-control studies (oral cancer patients vs healthy controls)

Alveolar bone loss did not differ significantly between oral cancer patients and controls (SMD 0.18, 95% CI -2.34 to 2.69; extreme heterogeneity); ungraded.

1 finding from 1 review

Occlusal splint vs Behavioural therapy (counselling, CBT, relaxation, self-care management)

Joint pain at rest · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes joint pain at rest compared with behavioural therapy (counselling, CBT, relaxation, self-care… (very low certainty).

1 finding from 1 review

Abdominal dermal fat graft vs Nasolabial flap

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether abdominal dermal fat graft changes maximal mouth opening (interincisal distance) compared with nasolabial flap (very low certainty).

2 findings from 1 review

Thermoelastic copper NiTi (CuNiTi) arch wire vs Conventional (stabilised) NiTi arch wire

Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

It is very uncertain whether thermoelastic copper NiTi (CuNiTi) arch wire changes alignment rate compared with conventional NiTi arch wire (very low certainty).

1 finding from 1 review

Slum / urban-disadvantaged setting vs Non-slum urban / general-urban / national population

Use of toothbrush and toothpaste for mouth cleaning · Adult residents of slums and non-slum urban settings of LMICs

Toothbrush/paste is the commonest cleaning method but is used less in slum/disadvantaged/rural groups than urban/non-slum groups; ungraded.

1 finding from 1 review

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT

Outcome not reported · Adults (> 18 years) with peri-implant mucositis, receiving supportive treatment

The review found no eligible studies for this question.

1 finding from 1 review

Consumption of xylitol chewing gum by women (mothers) vs Consumption of CHX/xylitol gum by women, or CHX varnish applied to women's dentition

Mother microbiological presence (mutans streptococci colonisation level, CFU/mL) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age

Consumption of xylitol chewing gum by women (mothers) led to higher mother microbiological presence (mutans streptococci colonisation… compared with consumption of CHX/xylitol gum by women, or CHX varnish applied to…; GRADE not reported.

1 finding from 1 review

Prenatal vitamin D deficiency (low maternal 25(OH)D during pregnancy) vs Adequate prenatal vitamin D (sufficient maternal 25(OH)D)

Dental caries · Children aged 2 to 8 years

The review reported an OR of 1.32 when prenatal vitamin D was measured at 6 to 38 gestational weeks.

2 findings from 1 review

Facemask vs no intervention

ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask probably leads to higher ANB compared with untreated control (no treatment) (moderate certainty).

3 findings from 1 review

Vasodilator vs Placebo or no active treatment

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether vasodilators (isoxsuprine, xanthinol nicotinate) changes burning sensation (VAS 0-100) compared with placebo or no active treatment (very low certainty).

2 findings from 1 review