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Evidence found and GRADE certainty

2,293 questions · 2,395 findings · 172 reviews · Gut

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No studies found 420 · 17.5%GRADE not reported 60 · 2.5%Very low 821 · 34.3%Low 602 · 25.1%Moderate 397 · 16.6%High 95 · 4%

Acupuncture vs medication

symptom severity (dichotomous outcome) Dichotomous measure of overall symptom severity1 · people with irritable bowel syndrome

Acupuncture may leads to higher symptom severity (dichotomous outcome) Dichotomous measure of… compared with pharmaceutical medications (low certainty).

1 finding from 1 review

Intervention not reported

Oesophageal cancer‐specific mortality ‐ not measured · patients with oesophageal cancer

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Secondary outcomes ‐ not measured · patients with oesophageal cancer

The review found no eligible studies for this question.

1 finding from 1 review

Curcumin vs placebo

Relapse at 6 months Clinical Disease Activty Index more than 42 · Maintenance of remission in ulcerative colitis

Curcumin showed no clear difference in relapse at 6 months Clinical Disease Activty Index more than 42 compared with placebo (low certainty).

1 finding from 1 review

Curcumin vs placebo

Relapse at 12 months Clinical Disease Activty Index more than 42 · Maintenance of remission in ulcerative colitis

Curcumin showed no clear difference in relapse at 12 months Clinical Disease Activty Index more than 42 compared with placebo (low certainty).

1 finding from 1 review

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Death Analysis 1.1 · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in all‐cause mortality, ITT analysis compared with early conservative management with or without delayed or selective… (low certainty).

1 finding from 1 review

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Local complications defined by the Atlanta Classification (necrosis, abscess, pseudocyst) · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in local complications defined by the Atlanta Classification (necrosis,… compared with early conservative management with or without delayed or selective… (moderate certainty).

1 finding from 1 review

Early routine ERCP strategy vs early conservative management with or without delayed or selective ERCP strategy

Systemic complications defined by the Atlanta Classification (organ failure including shock, pulmonary insufficiency, renal failure, and gastrointestinal bleeding; disseminated intravascular coagulation or severe metabolic disturbances) · patients with unselected patients with acute gallstone pancreatitis

Early routine ERCP strategy showed no clear difference in systemic complications defined by the Atlanta Classification (organ… compared with early conservative management with or without delayed or selective… (moderate certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of admission during ED stay · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) probably leads to lower rate of admission during ED stay compared with placebo (moderate certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of admission 72 hrs · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) showed no clear difference in rate of admission 72 hrs compared with placebo (low certainty).

2 findings from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration during ED stay · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) probably leads to lower rate of intravenous rehydration during ED stay compared with placebo (moderate certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration up to 72 hrs following discharge from ED (best ‐ worst scenario) · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) may leads to lower rate of intravenous rehydration up to 72 hrs following discharge… compared with placebo (low certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of intravenous rehydration up to 72 hrs following discharge from ED (worst ‐ best scenario) · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) may leads to lower rate of intravenous rehydration up to 72 hrs following discharge… compared with placebo (low certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Proportion of patients with cessation of vomiting · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) probably leads to higher proportion of patients with cessation of vomiting compared with placebo (moderate certainty).

1 finding from 1 review