Valgus knee brace vs no brace
Total number of adverse events (withdrawals due to lack of effect)c · patients with varus medial osteoarthritis of the knee
1 finding from 1 review
- no estimate extracted1 study · 117 participantsLow
Findings
What do systematic reviews say?
192 questions · 196 findings · 89 reviews
No studies found 31 · 15.8%GRADE not reported 18 · 9.2%Very low 68 · 34.7%Low 48 · 24.5%Moderate 24 · 12.2%High 7 · 3.6%
Intervention not reported
Total number of adverse events (withdrawals due to lack of effect)c · patients with varus medial osteoarthritis of the knee
The intervention showed no clear difference in total number of adverse events (withdrawals due to lack of effect)c (low certainty).
1 finding from 1 review
- RR 1.63 [0.94, 2.82]1 study · 117 participantsLow
Methotrexate vs placebo
Withdrawals due to adverse events · psoriatic arthritis
Methotrexate showed no clear difference in withdrawals due to adverse events (WAEs) assessed by number of events compared with placebo (low certainty).
1 finding from 1 review
- RR 1.32 [0.51, 3.42]3 studies · 293 participantsLow
Intervention not reported
Number of participant withdrawals due to adverse events ‐ not measured · patients with acute gout
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Zoledronate vs pamidronate or risedronate
Withdrawals due to adverse events · Paget's disease of bone
It is very uncertain whether zoledronate changes number of participants who withdrew due to adverse events… compared with pamidronate or risedronate (very low certainty).
1 finding from 1 review
- RR 2.04 [0.43, 9.59]2 studies · 437 participantsVery low
Intervention not reported
Severe adverse events or withdrawals (due to adverse events) ‐ not reported · People with hip or knee osteoarthritis
The review found no eligible studies for this question.
1 finding from 1 review
- High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Methotrexate vs other DMARDs
Withdrawals due to adverse events · psoriatic arthritis
2 findings from 1 review
- no estimate extracted2 studies · 61 participantsVery low
- RR 1.26 [0.33, 4.82]1 study · 35 participantsVery low
Shock wave therapy vs placebo
Number of participant withdrawals due to adverse events or treatment intolerance · rotator cuff disease
Shock wave therapy showed no clear difference in number of participant withdrawals due to adverse events or treatment… compared with placebo (low certainty).
1 finding from 1 review
- Shock wave therapy for rotator cuff disease with or without calcification 2020 · Cochrane Headline outcomes onlyRR 0.75 [0.43, 1.31]7 studies · 581 participantsLow
Certolizumab pegol 200 mg sc (with or without MTX) vs placebo (with or without MTX)
Withdrawals due to adverse events · patients with rheumatoid arthritis in adults
Certolizumab pegol 200 mg sc (with or without MTX) leads to higher withdrawals due to adverse events All doses of certolizumab pegol… compared with placebo (with or without MTX) (high certainty).
1 finding from 1 review
- Certolizumab pegol (CDP870) for rheumatoid arthritis in adults 2017 · Cochrane Headline outcomes onlyPeto OR 1.45 [1.09, 1.94]12 studies · 5236 participantsHigh
Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs Supra-gingival scaling
Adverse events (participants with adverse events or withdrawals due to adverse events) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
1 finding from 1 review
- SoF 2 (Adverse effects): 3 studies reported no adverse effects. 328 (3 studies); Moderate.3 studies · 328 participantsModerate
Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)
Adverse events (participants with adverse events or withdrawals due to adverse events) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
1 finding from 1 review
- SoF 1 (Adverse effects): Only 1 study reported that 1 participant in the treatment group experienced a myocardial infarction during the study period. 1 study reported no adverse effects. The remaining 2 studies did not…2 studies · 294 participantsLow
Calcium channel blockers vs placebo
Withdrawals due to adverse events · patients with Raynaud's phenomenon
Calcium channel blockers showed no clear difference in number of withdrawals due to adverse events Number of participants… compared with placebo (low certainty).
1 finding from 1 review
- Calcium channel blockers for primary and secondary Raynaud's phenomenon 2017 · Cochrane Headline outcomes onlyRR 1.3 [0.51, 3.33]2 studies · 63 participantsLow