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Evidence found and GRADE certainty

34 questions · 34 findings · 13 reviews

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No studies found 12 · 35.3%GRADE not reported 1 · 2.9%Very low 12 · 35.3%Low 6 · 17.6%Moderate 1 · 2.9%High 2 · 5.9%

Summary of findings table ‐ Deep neuromuscular blockade (NMB) vs moderate NMB

Short‐term serious adverse events (SAEs) · adults undergoing intra‐ and transperitoneal laparoscopic procedures

It is very uncertain whether summary of findings table ‐ Deep neuromuscular blockade (NMB) changes short‐term serious adverse events (SAEs) compared with moderate NMB (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Deep neuromuscular blockade (NMB) vs shallow NMB

Short‐term serious adverse events (SAEs) · adults undergoing intra‐ and transperitoneal laparoscopic procedures

It is very uncertain whether summary of findings table ‐ Deep neuromuscular blockade (NMB) changes short‐term serious adverse events (SAEs) compared with shallow NMB (very low certainty).

1 finding from 1 review

Methotrexate vs placebo

SAEs · psoriatic arthritis

Methotrexate showed no clear difference in serious adverse events (SAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review

LABA/LAMA vs LABA plus inhaled corticosteroid (ICS)

Number of participants experiencing any serious adverse events · stable COPD

Long‐acting muscarinic antagonist (LAMA) plus long‐acting… showed no clear difference in serious adverse events (number of people experiencing ≥ 1 SAEs) compared with LABA plus inhaled corticosteroid (ICS) (high certainty).

1 finding from 1 review

Summary of findings table ‐ Deep neuromuscular blockade (NMB) vs moderate NMB

Serious adverse events (SAEs) start of surgery until 8 hours after surgery · adults undergoing intra‐ and transperitoneal laparoscopic procedures

It is very uncertain whether summary of findings table ‐ Deep neuromuscular blockade (NMB) changes serious adverse events (SAEs) start of surgery until 8 hours after… compared with moderate NMB (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events (SAEs) ‐ Network included 31 pairwise comparisons ‐ Mean risk with SUN across trials3 included in this network: 40.7% · people with a confirmed diagnosis of advanced renal cell carcinoma (combined risk groups) without previous systemic anticancer therapy

The intervention showed no clear difference in serious adverse events (SAEs) ‐ Network included 31 pairwise… (moderate certainty).

1 finding from 1 review