Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,337 questions · 1,354 findings · 566 reviews

No studies found 307 · 22.7%GRADE not reported 81 · 6%Very low 424 · 31.3%Low 310 · 22.9%Moderate 189 · 14%High 43 · 3.2%

Antibiotics vs placebo

Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Serious adverse events ‐ total · individuals with moderate to severe disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in serious adverse events ‐ total compared with placebo or standard care alone (moderate certainty).

1 finding from 1 review

Plasma‐derived C1 esterase inhibitor vs placebo or active control

Serious adverse events (during · children or adults with Types I or II HAE

It is very uncertain whether plasma‐derived C1 esterase inhibitor changes serious adverse events (during compared with placebo or active control (very low certainty).

1 finding from 1 review

Recombinant human C1 esterase inhibitor vs placebo or active control

Serious adverse events (during · children or adults with Types I or II HAE

It is very uncertain whether recombinant human C1 esterase inhibitor changes serious adverse events (during compared with placebo or active control (very low certainty).

1 finding from 1 review