What do systematic reviews say?

Next‐generation ALK inhibitor vs crizotinib

It is very uncertain whether next‐generation ALK inhibitor changes health‐related quality of life: time to deterioration in composite… compared with crizotinib (very low certainty).

• Targeted therapy for advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer 2022 · Cochrane Headline outcomes only
  HR 1.1 [0.72, 1.68]
  1 study · 303 participants
  Very low

ALK inhibitor vs any cytotoxic chemotherapy

ALK inhibitor leads to lower health‐related quality of life: time to deterioration in composite… compared with any cytotoxic chemotherapy (high certainty).

• Targeted therapy for advanced anaplastic lymphoma kinase (ALK)‐rearranged non‐small cell lung cancer 2022 · Cochrane Headline outcomes only
  HR 0.52 [0.44, 0.6]
  5 studies · 1504 participants
  High

Primary health professionals and lay health workers vs usual care

• Primary‐level worker interventions for the care of people living with mental disorders and distress in low‐ and… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 53 participants
  Very low

Stroke ward vs general medical ward

• Organised inpatient (stroke unit) care for stroke: network meta‐analysis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 535 participants
  Very low

Organised inpatient (stroke unit) care vs alternative service

• Organised inpatient (stroke unit) care for stroke: network meta‐analysis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 843 participants
  Very low

Mepolizumab 100 mg vs placebo

• Anti‐IL‐5 therapies for chronic obstructive pulmonary disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1285 participants
  Moderate

Therapist‐supported ICBT vs unguided CBT

• Therapist‐supported Internet cognitive behavioural therapy for anxiety disorders in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 199 participants
  Very low

Therapist‐supported ICBT vs face‐to‐face CBT

• Therapist‐supported Internet cognitive behavioural therapy for anxiety disorders in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 392 participants
  Low

Therapist‐supported ICBT vs waiting list, attention, information, or online discussion group only control

• Therapist‐supported Internet cognitive behavioural therapy for anxiety disorders in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  23 studies · 1639 participants
  Moderate

PIMOZIDE vs antipsychotics

The review found no eligible studies for this question.

• Pimozide for schizophrenia or related psychoses 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

PIMOZIDE vs placebo

The review found no eligible studies for this question.

• Pimozide for schizophrenia or related psychoses 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Total hip arthroplasty vs hemiarthroplasty

• Arthroplasties for hip fracture in adults 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 279 participants
  Very low

Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors

• Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Antipsychotic dose increase vs antipsychotic dose continuation

• Increasing antipsychotic dose for non response in schizophrenia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 17 participants
  Low

Intervention not reported

• Swimming training for asthma in children and adolescents aged 18 years and under 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 50 participants
  Low

Rehabilitation interventions vs no intervention

The review found no eligible studies for this question.

• Interventions for perceptual disorders following stroke 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Lay health worker‐led psychological interventions vs usual care

• Primary‐level worker interventions for the care of people living with mental disorders and distress in low‐ and… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 1918 participants
  Moderate

Dietary interventions vs usual care

• Lifestyle changes for treating psoriasis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 36 participants
  Moderate

Fixed‐dose combination aclidinium/formoterol vs placebo

Fixed‐dose combination aclidinium/formoterol leads to higher quality of life: number of participants with clinically significant… compared with placebo (high certainty).

• Combined aclidinium bromide and long‐acting beta2‐agonist for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
  OR 1.72 [1.39, 2.13]
  2 studies · 1823 participants
  High

Fixed‐dose combination aclidinium/formoterol vs aclidinium alone

Fixed‐dose combination aclidinium/formoterol showed no clear difference in quality of life: number of participants with clinically significant… compared with aclidinium alone (moderate certainty).

• Combined aclidinium bromide and long‐acting beta2‐agonist for chronic obstructive pulmonary disease (COPD) 2018 · Cochrane Headline outcomes only
  OR 1.17 [0.97, 1.41]
  2 studies · 2002 participants
  Moderate