Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

28 questions · 30 findings · 15 reviews · Gynaecology and Fertility

No studies found 4 · 13.3%GRADE not reported 0 · 0%Very low 11 · 36.7%Low 13 · 43.3%Moderate 2 · 6.7%High 0 · 0%

Metformin vs placebo or no treatment

Miscarriage · women with polycystic ovary syndrome

Metformin showed no clear difference in miscarriage rate per woman compared with placebo or no treatment (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin combined with clomiphene citrate vs clomiphene

Miscarriage · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate showed no clear difference in miscarriage rate per woman compared with clomiphene citrate alone (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Human menopausal gonadotrophin or highly purified human menopausal gonadotrophin vs urinary follicle stimulating hormone

Miscarriage · ovulation induction in polycystic ovarian syndrome

It is very uncertain whether human menopausal gonadotrophin or highly purified human menopausal… changes miscarriage rate per woman compared with urinary follicle stimulating hormone (very low certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Miscarriage · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

Day 3 showed no clear difference in miscarriage rate per woman compared with day 2 embryo transfer following IVF or ICSI (moderate certainty).

1 finding from 1 review

Ultrasound‐guided transvaginal ovarian needle drilling with gonadotropin (Gn) vs Gn

Miscarriage · clomiphene‐resistant polycystic ovarian syndrome in subfertile women

It is very uncertain whether ultrasound‐guided transvaginal ovarian needle drilling with… changes miscarriage rate (per woman) compared with gn (very low certainty).

1 finding from 1 review

IVF vs unstimulated IUI

Miscarriage · women with unexplained subfertility

It is very uncertain whether IVF changes miscarriage rate per woman randomised compared with unstimulated IUI (very low certainty).

1 finding from 1 review