Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

32 questions · 36 findings · 19 reviews · Gynaecology and Fertility

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 12 · 33.3%Low 15 · 41.7%Moderate 9 · 25%High 0 · 0%

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin combined with clomiphene citrate vs clomiphene

Clinical pregnancy rate · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher clinical pregnancy rate per woman compared with clomiphene citrate alone (moderate certainty).

2 findings from 2 reviews · compare the 2 reviews

Recombinant follicle stimulating hormone vs urinary‐derived gonadotrophins

Clinical pregnancy rate · ovulation induction in polycystic ovarian syndrome

Recombinant follicle stimulating hormone showed no clear difference in clinical pregnancy rate per woman compared with urinary‐derived gonadotrophins (low certainty).

1 finding from 1 review

Human menopausal gonadotrophin or highly purified human menopausal gonadotrophin vs urinary follicle stimulating hormone

Clinical pregnancy rate · ovulation induction in polycystic ovarian syndrome

It is very uncertain whether human menopausal gonadotrophin or highly purified human menopausal… changes clinical pregnancy rate per woman compared with urinary follicle stimulating hormone (very low certainty).

1 finding from 1 review

Metformin vs placebo or no treatment

Clinical pregnancy rate · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Metformin probably leads to higher clinical pregnancy rate per woman compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (moderate certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonist or midcycle antagonist) (low certainty).

1 finding from 1 review

Day 3 vs Day 2 embryo transfer following IVF or ICSI

Clinical pregnancy rate · Women undergoing in vitro fertilisation or intracytoplasmic sperm injection

It is very uncertain whether day 3 changes clinical pregnancy rate per woman compared with day 2 embryo transfer following IVF or ICSI (very low certainty).

1 finding from 1 review

Intervention not reported

Clinical pregnancy rate per woman · Subfertile women

The intervention may leads to higher clinical pregnancy rate per woman (low certainty).

1 finding from 1 review

Intervention not reported

Clinical pregnancy rate per woman · Subfertile women

The intervention showed no clear difference in clinical pregnancy rate per woman (low certainty).

1 finding from 1 review

IVF vs expectant management

Clinical pregnancy rate · women with unexplained subfertility

It is very uncertain whether IVF changes clinical pregnancy rate per woman randomised compared with expectant management (very low certainty).

1 finding from 1 review

IVF vs unstimulated IUI

Clinical pregnancy rate · women with unexplained subfertility

It is very uncertain whether IVF changes clinical pregnancy rate per woman randomised compared with unstimulated IUI (very low certainty).

1 finding from 1 review