Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

70 questions · 74 findings · 30 reviews · Haematology

No studies found 16 · 21.6%GRADE not reported 4 · 5.4%Very low 23 · 31.1%Low 17 · 23%Moderate 10 · 13.5%High 4 · 5.4%

Aspirin vs vitamin K antagonist (VKA)

All‐cause mortality · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether aspirin (ASA) changes all‐cause mortality compared with vitamin K antagonist (VKA) (very low certainty).

2 findings from 1 review

Aspirin vs low molecular weight heparin

All‐cause mortality · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether aspirin (ASA) changes all‐cause mortality compared with low molecular weight heparin (LMWH) (very low certainty).

2 findings from 1 review

Vitamin K antagonists vs low molecular weight heparin

All‐cause mortality · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether vitamin K antagonist (VKA) changes all‐cause mortality compared with low molecular weight heparin (LMWH) (very low certainty).

2 findings from 1 review

Intervention not reported

28‐day all‐cause mortality · hospitalised adults with COVID‐19 (moderate to severe disease)

The intervention probably leads to lower 28‐day all‐cause mortality (moderate certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality at day 45 · non‐hospitalised adults with mild COVID‐19

The intervention showed no clear difference in all‐cause mortality at day 45 (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality at day 28 · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

It is very uncertain whether the intervention changes all‐cause mortality at day 28 (very low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality at day 28 · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in all‐cause mortality at day 28 (moderate certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

All‐cause mortality at day 28 · people with moderate to severe disease (WHO scale 4–9); all studies contributing results to the summary of findings table included people…

Azithromycin showed no clear difference in all‐cause mortality at day 28 compared with placebo or standard of care alone (high certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

All‐cause mortality at day 28 · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

Azithromycin showed no clear difference in all‐cause mortality at day 28 compared with placebo or standard of care alone (low certainty).

1 finding from 1 review