Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Gemcitabine plus oxaliplatin vs 5‐fluorouracil plus cisplatin plus radiotherapy

Serious adverse events · people with advanced biliary tract carcinomas

It is very uncertain whether gemcitabine plus oxaliplatin changes serious adverse events compared with 5‐fluorouracil plus cisplatin plus radiotherapy (very low certainty).

1 finding from 1 review

Macrolides vs placebo

Serious adverse events · children with bronchiectasis

Macrolides showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Serious adverse events · adults with bronchiectasis

Macrolides showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Usual care vs immunosuppressive withdrawal after combination therapy

Serious adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes serious adverse events compared with immunosuppressive withdrawal after combination therapy (very low certainty).

1 finding from 1 review

Exercise vs no exercise

Serious adverse events · people with Child‐Pugh stage A or B cirrhosis

Exercise showed no clear difference in serious adverse events compared with no exercise (low certainty).

1 finding from 1 review