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Oestrogen ring showed no clear difference in adverse events (total adverse events) (oestrogen ring vs placebo) compared with other regimens (moderate certainty).
It is very uncertain whether active cancer therapy combined with TCM changes adverse events ‐ white blood cell descent Diagnosed by clinicians compared with active cancer therapy (very low certainty).
Lidocaine may leads to higher adverse events (AEs; adverse drug reaction): drowsiness/dizziness compared with placebo or no intervention (low certainty).
Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; injury to pelvic organs compared with open myomectomy (all types) (moderate certainty).
It is very uncertain whether methylphenidate changes proportion of participants with one or more serious adverse events compared with placebo or no intervention (very low certainty).
It is very uncertain whether four per cent chlorhexidine + hand hygiene promotion changes authors reported adverse outcomes (events without hospitalisation) compared with usual care (very low certainty).
Yoga may leads to higher adverse events (1 participant withdrew due to increased back pain) compared with non‐exercise (low certainty).
It is very uncertain whether pharmacological interventions changes acceptability ‐ drop‐outs due to adverse events: post‐intervention compared with placebo (very low certainty).
It is very uncertain whether pazopanib plus lapatinib changes specific adverse events: gastrointestinal perforations or fistulae compared with lapatinib (very low certainty).
It is very uncertain whether pazopanib changes specific adverse events: gastrointestinal perforations or fistulae compared with lapatinib (very low certainty).
It is very uncertain whether cediranib plus chemotherapy changes specific adverse events: gastrointestinal perforations or fistulae compared with placebo plus chemotherapy (very low certainty).
Antioxidant(s) showed no clear difference in adverse events ‐ Multiple pregnancy№ of participants: 1886(9 RCTs) compared with placebo or no treatment/standard treatment (low certainty).
Sublingual immunotherapy showed no clear difference in serious adverse events Weighted mean duration of studies: 56 weeks compared with control (moderate certainty).
Irradiation with UV light: local narrow‐band UVB probably leads to higher primary: adverse events ‐ reported adverse events, mainly erythema compared with local PUVA (moderate certainty).
Oral retinoids: alitretinoin 30 mg leads to higher primary: adverse events ‐ headache Folluw‐up: 48 weeks to 72 weeks compared with placebo (high certainty).
It is very uncertain whether doxycycline changes adverse events Men and women Assessed by participants' self‐report compared with quinolones (very low certainty).