Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Intervention not reported

Adverse events ‐ shallow anterior chamber · People undergoing trabeculectomy surgery with glaucoma

It is very uncertain whether the intervention changes adverse events ‐ shallow anterior chamber (very low certainty).

1 finding from 1 review

Duodenum‐preserving pancreatic resection vs pancreaticoduodenectomy

Adverse events (number of adverse events) · people requiring surgery for chronic pancreatitis

It is very uncertain whether duodenum‐preserving pancreatic resection changes adverse events (number of adverse events) compared with pancreaticoduodenectomy (very low certainty).

1 finding from 1 review

Testosterone vs placebo

Withdrawals due to adverse events · men with sexual dysfunction

It is very uncertain whether testosterone changes treatment withdrawal due to adverse events compared with placebo (very low certainty).

2 findings from 1 review

Low‐intensity pulsed ultrasound vs control

Adverse events ‐ total of adverse events (Skin irritation) · acute fractures in adults; included studies assessed effects in complete upper limb fractures (distal radius, clavicle, scaphoid,…

It is very uncertain whether low‐intensity pulsed ultrasound changes adverse events Reported as skin irritation compared with control (very low certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Adverse events: all grades · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in adverse events (any grade) at up to day 28 compared with standard care (plus/minus placebo) (low certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Adverse events: all grades · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in adverse events: all grades within 6 months compared with placebo (low certainty).

2 findings from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events until data cut‐offb · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in serious adverse events until data cut‐offb compared with placebo (low certainty).

1 finding from 1 review