Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Celecoxib vs tNSAIDs

Number withdrawn due to adverse events · patients with osteoarthritis

Celecoxib showed no clear difference in number withdrawn due to adverse events compared with tNSAIDs (low certainty).

1 finding from 1 review

Celecoxib vs placebo

Number withdrawn due to adverse events · patients with osteoarthritis

Celecoxib showed no clear difference in number withdrawn due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

LAMA vs placebo

Adverse events after tiotropium 5.0 µg · adults and children with cystic fibrosis

LAMAs showed no clear difference in adverse events after tiotropium 5.0 µg compared with placebo (high certainty).

1 finding from 1 review

Specific allergen immunotherapy vs no immunotherapy

Any systemic reactions during therapy · adults and children with atopic eczema and inhalant allergen sensitisation

Specific allergen immunotherapy showed no clear difference in adverse events ‐ any systemic reaction compared with no immunotherapy (moderate certainty).

1 finding from 1 review

Paracetamol vs placebo

Serious adverse events Up to 12 weeks' · Patients with acute low‐back pain

Paracetamol showed no clear difference in serious adverse events Up to 12 weeks' compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Discontinuations due to adverse events · patients with rheumatoid arthritis

The intervention leads to higher discontinuations due to adverse events (high certainty).

1 finding from 1 review

Summary of findings table ‐ Concizumab prophylaxis vs on‐demand therapy

Adverse events ‐ Serious adverse events · people with inhibitors

Summary of findings table ‐ Concizumab prophylaxis showed no clear difference in adverse events ‐ Serious adverse events compared with on‐demand therapy (low certainty).

1 finding from 1 review

Summary of findings table ‐ Fitusiran prophylaxis vs on‐demand therapy

Adverse events ‐ Serious adverse events · people without inhibitors

Summary of findings table ‐ Fitusiran prophylaxis showed no clear difference in adverse events ‐ Serious adverse events compared with on‐demand therapy (moderate certainty).

1 finding from 1 review