Cochrane · systematic review · CD008774
Specific allergen immunotherapy for the treatment of atopic eczema
Tam, H, Calderon, MA, Manikam, L, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
SkinAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
6
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 50%Low 2 · 33.3%Moderate 1 · 16.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Specific allergen immunotherapy versus no immunotherapy
Population: adults and children with atopic eczema and inhalant allergen sensitisation
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Participant‐ or parent‐reported global assessment of disease severity Specific allergen immunotherapy vs no immunotherapy | no estimate extracted | 2 studies · 44 participants | Low Downgraded: imprecision, inconsistency |
Participant‐ or parent‐reported specific symptoms of eczema Specific allergen immunotherapy vs no immunotherapy | no estimate extracted | 6 studies · 339 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events ‐ any systemic reaction Specific allergen immunotherapy vs no immunotherapy | RR 0.78 [0.41, 1.49] | 7 studies · 492 participants | Moderate Downgraded: imprecision, indirectness |
Investigator‐ or physician‐rated global assessment of disease severity Specific allergen immunotherapy vs no immunotherapy | RR 1.48 [1.16, 1.88] | 7 studies · 286 participants | Very low Downgraded: risk of bias, imprecision |
Investigator‐ or physician‐rated eczema severity using a published scale Specific allergen immunotherapy vs no immunotherapy | no estimate extracted | 6 studies · 435 participants | Very low Downgraded: risk of bias, imprecision |
Participant or parent‐rated eczema severity using a published scale Specific allergen immunotherapy vs no immunotherapy | no estimate extracted | 2 studies · 184 participants | Low Downgraded: risk of bias, imprecision |