Cochrane · systematic review · CD012215
Dressings and topical agents containing hyaluronic acid for chronic wound healing
Roehrs, H, Stocco, JGD, Pott, F, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
WoundsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
54
current version
GRADE rated
26
No studies
27
Included studies
NR
No studies 27 · 50%Ungraded 1 · 1.9%Very low 23 · 42.6%Low 2 · 3.7%Moderate 1 · 1.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Platelet‐rich growth factor + hyaluronic acid compared with platelet‐rich growth factor for pressure ulcers
Population: pressure ulcer
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete ulcer healing Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor | RR 1.17 [0.58, 2.35] | 1 study · 65 participants | Very low Downgraded: risk of bias, imprecision |
Time to complete wound healing ‐ not reported Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor | no estimate extracted | NR | No studies |
Adverse events Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor | no estimate extracted | 1 study · 65 participants | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor | no estimate extracted | NR | No studies |
Pain Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor | no estimate extracted | NR | No studies |
Change in ulcer size Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor | MD 25.6 | 1 study · 65 participants | Very low Downgraded: risk of bias, imprecision |
Lysine hyaluronate compared with sodium hyaluronate for pressure ulcers
Population: people with pressure ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete ulcer healing Lysine hyaluronate vs sodium hyaluronate | RR 2.5 [0.71, 8.83] | 1 study · 10 participants | Very low Downgraded: risk of bias, imprecision |
Time to complete wound healing ‐ not reported Lysine hyaluronate vs sodium hyaluronate | no estimate extracted | NR | No studies |
Adverse events ‐ not reported Lysine hyaluronate vs sodium hyaluronate | no estimate extracted | NR | No studies |
Health‐related quality of life ‐ not reported Lysine hyaluronate vs sodium hyaluronate | no estimate extracted | NR | No studies |
Pain Lysine hyaluronate vs sodium hyaluronate | no estimate extracted | NR | No studies |
Change in ulcer size Lysine hyaluronate vs sodium hyaluronate | no estimate extracted | 1 study · 10 participants | Very low Downgraded: risk of bias, imprecision |
Hyaluronic acid compared with lyophilised collagen for foot ulcers in people with diabetes
Population: foot ulcers in people with diabetes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete ulcer healing Hyaluronic acid vs lyophilised collagen | no estimate extracted | 1 study · 20 participants | Ungraded |
Time to complete healing Hyaluronic acid vs lyophilised collagen | MD 16.6 | 1 study · 20 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events ‐ not reported Hyaluronic acid vs lyophilised collagen | no estimate extracted | NR | No studies |
Health‐related quality of life ‐ not reported Hyaluronic acid vs lyophilised collagen | no estimate extracted | NR | No studies |
Pain Hyaluronic acid vs lyophilised collagen | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
Change in ulcer size Hyaluronic acid vs lyophilised collagen | no estimate extracted | NR | No studies |
Hyaluronic acid compared with conventional dressing (sterile petrolatum gauze) for foot ulcers in people with diabetes
Population: foot ulcers in people with diabetes
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete ulcer healing (12 weeks ‐ 84 days) Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) | RR 2.2 [0.97, 4.97] | 1 study · 34 participants | Very low Downgraded: risk of bias, imprecision |
Time to complete wound healing ‐ not reported Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) | no estimate extracted | NR | No studies |
Adverse events ‐ not measured Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life ‐ not reported Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) | no estimate extracted | NR | No studies |
Pain Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) | no estimate extracted | NR | No studies |
Change in ulcer size Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) | MD 0.8 | 1 study · 25 participants | Very low Downgraded: risk of bias, imprecision |
Hyaluronic acid + hydrocolloid compared with hydrocolloid for leg ulcers
Population: people with leg ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete ulcer healing (42 days) Hyaluronic acid + hydrocolloid vs hydrocolloid | RR 0.98 [0.26, 3.76] | 1 study · 125 participants | Very low Downgraded: risk of bias, imprecision |
Time to complete wound healing ‐ not reported Hyaluronic acid + hydrocolloid vs hydrocolloid | no estimate extracted | NR | No studies |
Adverse events Hyaluronic acid + hydrocolloid vs hydrocolloid | RR 0.79 [0.22, 2.8] | 1 study · 125 participants | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life ‐ not reported Hyaluronic acid + hydrocolloid vs hydrocolloid | no estimate extracted | NR | No studies |
Pain (VAS, mm) at Hyaluronic acid + hydrocolloid vs hydrocolloid | MD 2.1 | 1 study · 125 participants | Very low Downgraded: risk of bias, imprecision |
Change in ulcer size to at least 90% Hyaluronic acid + hydrocolloid vs hydrocolloid | RR 2.11 [0.92, 4.82] | 1 study · 125 participants | Very low Downgraded: risk of bias, imprecision |
Hyaluronic acid compared with hydrocolloid for leg ulcers
Population: people with leg ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete ulcer healing Hyaluronic acid vs hydrocolloid | no estimate extracted | 1 study · 143 participants | Very low Downgraded: risk of bias, imprecision |
Time to complete wound healing ‐ not reported Hyaluronic acid vs hydrocolloid | no estimate extracted | NR | No studies |
Adverse events Hyaluronic acid vs hydrocolloid | no estimate extracted | 1 study · 143 participants | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life ‐ not reported Hyaluronic acid vs hydrocolloid | no estimate extracted | NR | No studies |
Pain Hyaluronic acid vs hydrocolloid | no estimate extracted | NR | No studies |
Change in ulcer size > 40% Hyaluronic acid vs hydrocolloid | RR 1.02 [0.84, 1.25] | 1 study · 143 participants | Very low Downgraded: risk of bias, imprecision |
Hyaluronic acid compared with paraffin gauze for leg ulcers
Population: leg ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete ulcer healing (56 days) Hyaluronic acid vs paraffin gauze | RR 2 [0.21, 19.23] | 1 study · 17 participants | Very low Downgraded: risk of bias, imprecision |
Time to complete wound healing ‐ not reported Hyaluronic acid vs paraffin gauze | no estimate extracted | NR | No studies |
Adverse events ‐ not reported Hyaluronic acid vs paraffin gauze | no estimate extracted | NR | No studies |
Health‐related quality of life ‐ not reported Hyaluronic acid vs paraffin gauze | no estimate extracted | NR | No studies |
Pain Hyaluronic acid vs paraffin gauze | no estimate extracted | NR | No studies |
Change in ulcer size Hyaluronic acid vs paraffin gauze | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision |
Hyaluronic acid compared with neutral vehicle for leg ulcers
Population: people with leg ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete wound healing (60 days) Hyaluronic acid vs neutral vehicle | RR 2.11 [1.46, 3.07] | 4 studies · 526 participants | Moderate Downgraded: risk of bias, imprecision |
Time to complete wound healing Hyaluronic acid vs neutral vehicle | no estimate extracted | 1 study · 89 participants | Very low Downgraded: risk of bias, imprecision |
Adverse events ‐ incidence of infection Hyaluronic acid vs neutral vehicle | RR 0.89 [0.53, 1.49] | 3 studies · 425 participants | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life ‐ not reported Hyaluronic acid vs neutral vehicle | no estimate extracted | NR | No studies |
Pain (VAS, mm), reduction from baseline Hyaluronic acid vs neutral vehicle | no estimate extracted | 3 studies · 337 participants | Low Downgraded: risk of bias, imprecision |
Change in ulcer size (45 days) Hyaluronic acid vs neutral vehicle | no estimate extracted | 2 studies · 190 participants | Low Downgraded: risk of bias, imprecision |
Hyaluronic acid compared with dextranomer for leg ulcers
Population: people with leg ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Complete ulcer healing ‐ not reported Hyaluronic acid vs dextranomer | no estimate extracted | NR | No studies |
Time to complete wound healing ‐ not reported Hyaluronic acid vs dextranomer | no estimate extracted | NR | No studies |
Adverse events Hyaluronic acid vs dextranomer | no estimate extracted | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision |
Health‐related quality of life ‐ not reported Hyaluronic acid vs dextranomer | no estimate extracted | NR | No studies |
Pain Hyaluronic acid vs dextranomer | no estimate extracted | NR | No studies |
Change in ulcer size (21 days) Hyaluronic acid vs dextranomer | MD 5.8 | 1 study · 50 participants | Very low Downgraded: risk of bias, imprecision |