Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Intervention not reported

Adverse events ‐ recurrent fever · acute bacterial meningitis

The intervention probably leads to higher adverse events ‐ recurrent fever (moderate certainty).

1 finding from 1 review

Chondroitin vs placebo

Number of serious adverse events · patients with osteoarthritis

Chondroitin probably leads to lower number of serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Capsaicin vs placebo

Treatment‐related adverse events · non‐allergic rhinitis

The review found no eligible studies for this question.

1 finding from 1 review

Capsaicin vs budesonide

Treatment‐related adverse events · patients with non‐allergic rhinitis

The review found no eligible studies for this question.

1 finding from 1 review

Diacerein vs placebo

Withdrawals due to adverse events · patients with osteoarthritis

Diacerein showed no clear difference in withdrawal due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Metformin vs clomiphene

Gastrointestinal adverse events · women with polycystic ovary syndrome

The review found no eligible studies for this question.

2 findings from 2 reviews · compare the 2 reviews

Intermittent/cyclic etidronate 400 mg/day vs placebo

Withdrawals due to adverse events · postmenopausal women with a higher risk for fracturesa

It is very uncertain whether intermittent/cyclic etidronate 400 mg/day changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review