Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Back School vs combined myofascial therapy and joint manipulation

Adverse events Number of events · participants with acute or subacute low‐back pain

It is very uncertain whether back school changes adverse events Number of events compared with combined myofascial therapy and joint manipulation (very low certainty).

1 finding from 1 review

Enhanced recovery protocol vs usual care

Serious adverse events (number) · people with major upper gastrointestinal, liver and pancreatic surgery

It is very uncertain whether enhanced recovery protocol changes serious adverse events (number) compared with standard care (very low certainty).

1 finding from 1 review

Stopping LABA vs continuing use of LABA+ICS

Serious adverse events 17 weeks · adults with asthma well controlled on LABA and ICS

Stopping LABA showed no clear difference in serious adverse events 17 weeks compared with continuing use of LABA+ICS (moderate certainty).

1 finding from 1 review

LAMA add‐on vs long‐acting beta2‐agonists (LABA) add‐on

Serious adverse events 22 weeks · adults with asthma not well controlled on ICS

Long‐acting muscarinic antagonists (LAMA) add‐on showed no clear difference in serious adverse events 22 weeks compared with long‐acting beta2‐agonists (LABA) add‐on (low certainty).

1 finding from 1 review

Preformed metal crown (stainless steel), conventional technique vs Aesthetic crown (stainless steel with composite/white veneer), conventional technique

Adverse events: bone resorption · Children with decayed primary molar teeth
1 finding from 1 review
  • Preformed crowns for decayed primary molar teeth 2015 · Cochrane All outcomes
    Six months and four years
    Bone resorption: one case at six months in a tooth treated with a veneer crown; no bone resorption at either the veneer crown or stainless steel sites at four-year follow-up (Analysis 3.2).
    1 study · 11 participants
    Very low

Intrauterine infusion/injection of autologous platelet‐rich plasma vs placebo or no intervention

Adverse events: preterm delivery · women undergoing assisted reproduction

Intrauterine infusion/injection of autologous platelet‐rich plasma may leads to higher adverse events: preterm delivery compared with no intervention or placebo (low certainty).

1 finding from 1 review