Cochrane · systematic review · CD011160
Anti‐vascular endothelial growth factor for choroidal neovascularisation in people with pathological myopia
Zhu, Y, Zhang, T, Xu, G, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 28.6%Low 2 · 28.6%Moderate 3 · 42.9%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Anti‐VEGF compared with control for choroidal neovascularisation in people with pathological myopia
Population: CNV in people with pathologic myopia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in visual acuity at 1 year Anti‐VEGF vs control | no estimate extracted | 3 studies · 263 participants | Low Downgraded: imprecision, inconsistency |
Gain 3+ lines of visual acuity at 1 year Anti‐VEGF vs control | RR 1.86 [1.27, 2.73] | 2 studies · 226 participants | Moderate Downgraded: inconsistency |
Change in central macular thickness at 1 year Anti‐VEGF vs control | no estimate extracted | 2 studies · 226 participants | Moderate Downgraded: imprecision |
CNV angiographic closure at 1 year Anti‐VEGF vs control | RR 1.24 [0.99, 1.54] | 2 studies · 208 participants | Low Downgraded: imprecision, inconsistency |
Systemic serious adverse events Anti‐VEGF vs control | RR 4.5 [0.6, 33.99] | 4 studies · 508 participants | Very low Downgraded: imprecision, inconsistency, indirectness |
Ocular adverse events Anti‐VEGF vs control | RR 1.82 [0.23, 14.71] | 4 studies · 508 participants | Very low Downgraded: imprecision, inconsistency, indirectness |
Quality of life Anti‐VEGF vs control | no estimate extracted | 1 study · 121 participants | Moderate Downgraded: imprecision |