Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,918 questions · 5,537 findings · 1,803 reviews

No studies found 1,309 · 23.6%GRADE not reported 440 · 7.9%Very low 1,560 · 28.2%Low 1,292 · 23.3%Moderate 751 · 13.6%High 185 · 3.3%

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Bortezomib vs no bortezomib

Diarrhoea · All patients with a diagnosis of multiple myeloma

Bortezomib may leads to higher adverse Events: Diarrhoea compared with no bortezomib (low certainty).

3 findings from 1 review

Antibiotics vs other antibiotics

Non‐serious adverse events · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes non‐serious adverse events compared with other antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Non‐serious adverse events · farmworkers, soldiers, and people in endemic areas

It is very uncertain whether summary of findings table ‐ Antibiotics changes non‐serious adverse events compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events – pneumonia · adults after cardiopulmonary resuscitation

The intervention showed no clear difference in adverse events – pneumonia (low certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs placebo/open control

All serious adverse events · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Antifibrinolytic drug(s) showed no clear difference in all serious adverse events compared with placebo/open control (high certainty).

1 finding from 1 review

Summary of findings table ‐ Platelet transfusion vs open control

All serious adverse events · adults with acute spontaneous intracerebral haemorrhage associated with antiplatelet drug use

Summary of findings table ‐ Platelet transfusion showed no clear difference in all serious adverse events compared with open control (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs fresh frozen plasma

All serious adverse events · adults with acute spontaneous intracerebral haemorrhage associated with anticoagulant drug use

It is very uncertain whether summary of findings table ‐ Prothrombin complex concentrates changes all serious adverse events compared with fresh frozen plasma (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Recombinant activated factor VII vs placebo/open control

All serious adverse events · adults with acute spontaneous intracerebral haemorrhage

It is very uncertain whether summary of findings table ‐ Recombinant activated factor VII changes all serious adverse events compared with placebo/open control (very low certainty).

1 finding from 1 review

Blood pressure intervention/intensive blood pressure intervention vs placebo/standard blood pressure intervention

Adverse events: hypotension · type 1 or type 2 diabetics

Blood pressure intervention/intensive blood pressure intervention may leads to higher adverse events—hypotension compared with placebo/standard blood pressure intervention (low certainty).

1 finding from 1 review

Intervention not reported

Secondary ‐ Adverse events · Patients with acute uncomplicated diverticulitis

The intervention showed no clear difference in secondary ‐ Adverse events (moderate certainty).

1 finding from 1 review

Rotarix vs placebo

All serious adverse events · children

Rotarix leads to lower all serious adverse events compared with placebo (high certainty).

3 findings from 1 review

RotaTeq vs placebo

All serious adverse events · children

RotaTeq showed no clear difference in all serious adverse events compared with placebo (high certainty).

3 findings from 1 review