Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

1,949 questions · 1,994 findings · 636 reviews

No studies found 504 · 25.3%GRADE not reported 340 · 17.1%Very low 477 · 23.9%Low 390 · 19.6%Moderate 241 · 12.1%High 42 · 2.1%

Desloratadine 5 to 20 mg vs placebo

Adverse effects requiring withdrawal/discontinuation of study medication · patients with chronic spontaneous urticaria

Desloratadine 5 to 20 mg showed no clear difference in adverse effects leading to withdrawal: intermediate‐term duration of… compared with placebo (low certainty).

1 finding from 1 review

SULPIRIDE AUGMENTATION OF ANY ANTIPSYCHOTIC DRUG vs antipsychotics

Specific adverse effects: 4. Gastrointestinal system ‐ short term ‐ salavation ‐ too much · patients with schizophrenia

SULPIRIDE AUGMENTATION OF ANY ANTIPSYCHOTIC DRUG may leads to lower specific adverse effects: 4. Gastrointestinal system ‐ short term ‐… compared with ANY ANTIPSYCHOTIC DRUG (low certainty).

1 finding from 1 review

Exercise vs usual care

Adverse effects associated with exercises Exercise programme duration: range 3 to 24 weeks · adults with ankylosing spondylitis

It is very uncertain whether exercise programmes changes adverse effects associated with exercises Exercise programme… compared with usual care (very low certainty).

1 finding from 1 review

Exercise vs no intervention

Adverse effects associated with exercises Exercise programme duration: range 3 to 24 weeks · adults with ankylosing spondylitis

It is very uncertain whether exercise programmes changes adverse effects associated with exercises Exercise programme… compared with no intervention (very low certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention ‐ aciclovir 800 mg twice daily · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention ‐… compared with placebo (moderate certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention ‐ aciclovir 400 mg twice daily · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention ‐… compared with placebo (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Adverse effects: Specific ‐ dystonia during 24 hours · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in adverse effects: Movement disorders ‐ dystonia (spasmodic postural… compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

STANDARD‐HIGHER DOSE (greater than or equal to 6‐<10 mg/day) vs ANY DOSE ‐ short term

Adverse effects: 6. Movement disorders ‐ specific symptoms ‐ EPS: unspecified ‐ versus low dose (greater than or equal to 2‐<4 mg/day) · patients with schizophrenia

STANDARD‐HIGHER DOSE (greater than or equal to 6‐<10 mg/day) showed no clear difference in adverse effects: EPS: unspecified ‐ Versus low dose (greater than or… compared with ANY DOSE ‐ short term (moderate certainty).

1 finding from 1 review

Whole‐facility changes: Home‐like models vs traditional environment

Serious adverse effects Physical restraints, reported as percentage points (lower = better) · older adults living in long‐term residential care including, but not limited to, dementia‐specific care settings

It is very uncertain whether whole‐facility changes: Home‐like models changes serious adverse effects Physical restraints, reported as percentage… compared with traditional environment (very low certainty).

1 finding from 1 review

Etanercept vs corticosteroids

Adverse effects leading to discontinuation of SJT/TEN therapy ‐ not reported · Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Group B cognitive behavioural therapy: cognitive behavioural therapy + risperidone vs placebo and cognitive and behavioural therapies

Adverse effects: specific ‐ doctors' assessment of adverse effects UKU (events) Medium‐term · people in the prodromal stage of psychosis

It is very uncertain whether group B cognitive behavioural therapy: cognitive behavioural therapy… changes adverse effects: specific ‐ doctors' assessment of adverse effects… compared with cognitive behavioural therapy + placebo (very low certainty).

1 finding from 1 review

Group C cognitive behavioural therapy: cognitive behavioural therapy + placebo vs placebo or supportive treatment

Adverse effects: specific ‐ doctors' assessment of adverse effects UKU (events) Medium‐term · people in the prodromal stage of psychosis

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes adverse effects: specific ‐ doctors' assessment of adverse effects… compared with supportive therapy + placebo (very low certainty).

1 finding from 1 review

Itraconazole (200 mg for 6 to 8 weeks) vs placebo

Adverse effects Mild abdominal pain and nausea Adverse effects Mild abnormal liver function · patients with Old World cutaneous leishmaniasis

It is very uncertain whether itraconazole (200 mg for 6 to 8 weeks) changes adverse effects Mild abdominal pain and nausea Adverse effects Mild… compared with placebo (very low certainty).

1 finding from 1 review

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) vs MEDIUM DOSE (401 mg/day to 800 mg/day)

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) probably leads to lower adverse effects: extrapyramidal symptoms (unspecified extrapyramidal… compared with MEDIUM DOSE (401 mg/day to 800 mg/day) (moderate certainty).

1 finding from 1 review

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ pre‐ and postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

SULPIRIDE AUGMENTATION OF ANY ANTIPSYCHOTIC DRUG vs antipsychotics

Adverse events: Movement disorder ‐ any extra pyramidal symptoms ‐ short term · patients with schizophrenia

It is very uncertain whether SULPIRIDE AUGMENTATION OF ANY ANTIPSYCHOTIC DRUG changes specific adverse effects: 1a. CNS ‐ short term ‐ movement disorder ‐… compared with ANY ANTIPSYCHOTIC DRUG (very low certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride vs sulpiride

Adverse effects: Clinically important general adverse effect ‐ requiring hypnotics/sedatives · schizophrenia

It is very uncertain whether zuclopenthixol dihydrochloride changes adverse effects: Clinically important general adverse effect ‐… compared with sulpiride (very low certainty).

1 finding from 1 review