Studies
Primary studies
26,293 studies included by 1,022 non-Cochrane dental reviews extracted from full text, one record per study, so a study included by several reviews is counted once. Most are randomized trials; etiology and diagnostic reviews also include observational and accuracy studies. Cochrane reviews and reviews with only their headline outcomes do not list their included studies here yet.
ReviewStudies included by MicroRNAs as diagnostic biomarkers in periodontitis: a systematic review and meta-analysis.. Show all studies
| Study | Year | Reviews | Review outcomes linked | Trial data |
|---|---|---|---|---|
| Comparative evaluation of macrophage polarization markers- nitric oxide, sCD163 and miRNA-21 in the saliva of healthy, gingivitis and periodontitis… Akshaya 2025 · Akshaya J., Victor Dhayanand John, et al. · Gene Reports DOI:10.1016/j.genrep.2025.102213 | 2025 | 1 | none stated | not extracted yet |
| Clinical significance analysis of microRNA-199a-3p in gingival crevicular fluid for patients with chronic periodontitis Yan 2025 · Yan Kaixuan, Zheng Yu, et al. · Molecular and Cellular Probes DOI:10.1016/j.mcp.2025.102015 | 2025 | 1 | none stated | not extracted yet |
| High Mobility Group Box-1 (HMGB1)/microRNA-155 Axis in the Pathogenesis of Type 2 Diabetes Mellitus Associated Periodontitis: A Case Control Study Appukuttan 2025 · Appukuttan Devapriya, Subramanian Sangeetha, et al. · Journal of Advanced Oral Research DOI:10.1177/23202068241308668 | 2025 | 1 | 1 | not extracted yet |
| Clinical significance analysis of microRNA-199a-3p in gingival crevicular fluid for patients with chronic periodontitis. Yan 2025 · Yan Kaixuan, Zheng Yu, et al. · Molecular and cellular probes PMID:39870183 | 2025 | 1 | none stated | not extracted yet |
| Expression of microRNA-223 and microRNA-214 in gingival crevicular fluid of smoker and nonsmoker periodontitis patients, an observational diagnostic… AbdelKawy 2024 · AbdelKawy Maha, Tarrad Nayroz Abdel Fattah, et al. · Clinical Oral Investigations DOI:10.1007/s00784-024-05844-7 | 2024 | 1 | 1 | not extracted yet |
| The Evaluation of a 5-miRNA Panel in Patients with Periodontitis Disease Baru 2025 · Baru O., Pop L., et al. · JDR Clinical & Translational Research DOI:10.1177/23800844241252395 | 2024 | 1 | 1 | not extracted yet |
| Expression Levels of miR-181 Family Members in Oral Biofluids as Biomarkers for Periodontitis Severity Li 2024 · Li Qun, Zhu Jin-Juan · The Tohoku Journal of Experimental Medicine DOI:10.1620/tjem.2024.j058 | 2024 | 1 | none stated | not extracted yet |
| Expression Levels of miR-181 Family Members in Oral Biofluids as Biomarkers for Periodontitis Severity. Li 2024 · Li Qun, Zhu Jin-Juan · The Tohoku journal of experimental medicine PMID:38960640 | 2024 | 1 | none stated | not extracted yet |
| Expression dynamics of microRNA-223/Ras-associated binding protein 12 axis in Stage III/Grade B periodontal disease: A case-control analysis. Bandi 2024 · Bandi Dhathri Priya, Sudhakar Uma, et al. · Journal of Indian Society of Periodontology PMID:38988960 | 2024 | 1 | 1 | not extracted yet |
| Expression of microRNA-223 and microRNA-214 in gingival crevicular fluid of smoker and nonsmoker periodontitis patients, an observational diagnostic… AbdelKawy 2024 · AbdelKawy Maha, Tarrad Nayroz Abdel Fattah, et al. · Clinical oral investigations PMID:39126506 | 2024 | 1 | 1 | not extracted yet |
| TNFα, IL-6, miR-103a-3p, miR-423-5p, miR-23a-3p, miR-15a-5p and miR-223-3p in the crevicular fluid of periodontopathic patients correlate with each… Costantini 2023 · Costantini Erica, Sinjari Bruna, et al. · Scientific Reports DOI:10.1038/s41598-022-26421-6 | 2023 | 1 | none stated | not extracted yet |
| Non-invasive diagnostic potential of salivary miR-25-3p for periodontal disease and osteoporosis among a cohort of elderly patients with type 2… Ni 2023 · Ni Jing, Zhang Qiong, et al. · BMC Oral Health DOI:10.1186/s12903-023-02992-2 | 2023 | 1 | none stated | not extracted yet |
| Diagnostic potential of miR-200 family members in gingival crevicular fluid for chronic periodontitis: correlation with clinical parameters and… Yu 2023 · Yu Shi-Lei · BMC Oral Health DOI:10.1186/s12903-023-03174-w | 2023 | 1 | none stated | not extracted yet |
| MicroRNA‐155 (miR-155) as an accurate biomarker of periodontal status and coronary heart disease severity: a case–control study Daily 2023 · Daily Zina A., Al-Ghurabi Batool Hassan, et al. · BMC Oral Health DOI:10.1186/s12903-023-03584-w | 2023 | 1 | 1 | not extracted yet |
| Identification of a miRNA Panel with a Potential Determinant Role in Patients Suffering from Periodontitis Baru 2023 · Baru Oana, Raduly Lajos, et al. · Current Issues in Molecular Biology DOI:10.3390/cimb45030145 | 2023 | 1 | none stated | not extracted yet |
| Gingival Tissue MiRNA Expression Profiling and an Analysis of Periodontitis-Specific Circulating MiRNAs Buragaite-Staponkiene 2023 · Buragaite-Staponkiene Benita, Rovas Adomas, et al. · International Journal of Molecular Sciences DOI:10.3390/ijms241511983 | 2023 | 1 | none stated | not extracted yet |
| Extracellular microRNA-223-5p Levels in Plasma, Saliva, and Gingival Crevicular Fluid in Periodontal Disease as a Potential Diagnostic Marker − A… Bandi 2023a · Bandi Dhathri Priya, Sudhakar Uma, et al. · Journal of Orofacial Sciences DOI:10.4103/jofs.jofs_177_23 | 2023 | 1 | 1 | not extracted yet |
| MicroRNA-221-5p, MicroRNA-222-5p, and MicroRNA-223-5p Expression Patterns in Association with the Pathogenesis of Periodontal Disease: A… Bandi 2023b · Sudhakar Uma, Bandi Dhathri P, et al. · World Journal of Dentistry DOI:10.5005/jp-journals-10015-2310 | 2023 | 1 | 1 | not extracted yet |
| TNFα, IL-6, miR-103a-3p, miR-423-5p, miR-23a-3p, miR-15a-5p and miR-223-3p in the crevicular fluid of periodontopathic patients correlate with each… Costantini 2023 · Costantini Erica, Sinjari Bruna, et al. · Scientific reports PMID:36599866 | 2023 | 1 | none stated | not extracted yet |
| Identification of a miRNA Panel with a Potential Determinant Role in Patients Suffering from Periodontitis. Baru 2023 · Baru Oana, Raduly Lajos, et al. · Current issues in molecular biology PMID:36975515 | 2023 | 1 | none stated | not extracted yet |
| Non-invasive diagnostic potential of salivary miR-25-3p for periodontal disease and osteoporosis among a cohort of elderly patients with type 2… Ni 2023 · Ni Jing, Zhang Qiong, et al. · BMC oral health PMID:37221590 | 2023 | 1 | none stated | not extracted yet |
| Diagnostic potential of miR-200 family members in gingival crevicular fluid for chronic periodontitis: correlation with clinical parameters and… Yu 2023 · Yu Shi-Lei · BMC oral health PMID:37525201 | 2023 | 1 | none stated | not extracted yet |
| Gingival Tissue MiRNA Expression Profiling and an Analysis of Periodontitis-Specific Circulating MiRNAs. Buragaite-Staponkiene 2023 · Buragaite-Staponkiene Benita, Rovas Adomas, et al. · International journal of molecular sciences PMID:37569358 | 2023 | 1 | none stated | not extracted yet |
| MicroRNA-155 (miR-155) as an accurate biomarker of periodontal status and coronary heart disease severity: a case-control study. Daily 2023 · Daily Zina A, Al-Ghurabi Batool Hassan, et al. · BMC oral health PMID:37974134 | 2023 | 1 | 1 | not extracted yet |
| MicroRNAs in Gingival Crevicular Fluid: An Observational Case-Control Study of Differential Expression in Periodontitis. Almiñana-Pastor 2023 · Almiñana-Pastor Pedro J, Alpiste-Illueca Francisco M, et al. · Non-coding RNA PMID:37987369 | 2023 | 1 | 1 | not extracted yet |
| RETRACTED: MicroRNA-28-5p as a potential diagnostic biomarker for chronic periodontitis and its role in cell proliferation and inflammatory response Huang 2022 · Huang Pengcheng, Jia Linghui · Journal of Dental Sciences DOI:10.1016/j.jds.2022.04.031 | 2022 | 1 | none stated | not extracted yet |
| Correlation Analysis of miR-1246 Expression in Saliva of Patients with Chronic Periodontitis and Periodontal Indexes, Inflammatory Cytokines, and… Wu 2022 · Wu Shuainan, Li Zhaobao, et al. · Evidence-Based Complementary and Alternative Medicine DOI:10.1155/2022/1949159 | 2022 | 1 | none stated | not extracted yet |
| The expression and clinical significance of miR-30b-3p and miR-125b-1-3p in patients with periodontitis Zhu 2022 · Zhu Jinjuan, Zhong Zhihong · BMC Oral Health DOI:10.1186/s12903-022-02360-6 | 2022 | 1 | none stated | not extracted yet |
| Role of miRNA-155 in the regulation of osteoclast differentiation mediated by MITF in stage III/IV periodontitis: a case-control study Nandipati 2022 · Nandipati Sowmya Reddy, Appukuttan Devapriya, et al. · Journal of Genetic Engineering and Biotechnology DOI:10.1186/s43141-022-00441-1 | 2022 | 1 | 1 | not extracted yet |
| Gingival crevicular fluid microRNA associations with periodontitis Rovas 2022 · Rovas Adomas, Puriene Alina, et al. · Journal of Oral Science DOI:10.2334/josnusd.21-0282 | 2022 | 1 | 1 | not extracted yet |
| Gingival crevicular fluid microRNA associations with periodontitis. Rovas 2022 · Rovas Adomas, Puriene Alina, et al. · Journal of oral science PMID:34690249 | 2022 | 1 | 1 | not extracted yet |
| The expression and clinical significance of miR-30b-3p and miR-125b-1-3p in patients with periodontitis. Zhu 2022 · Zhu Jinjuan, Zhong Zhihong · BMC oral health PMID:35931990 | 2022 | 1 | none stated | not extracted yet |
| Correlation Analysis of miR-1246 Expression in Saliva of Patients with Chronic Periodontitis and Periodontal Indexes, Inflammatory Cytokines, and… Wu 2022 · Wu Shuainan, Li Zhaobao, et al. · Evidence-based complementary and alternative medicine : eCAM PMID:35942384 | 2022 | 1 | none stated | not extracted yet |
| Relationship between microRNA expression and inflammatory factors in patients with both type 2 diabetes mellitus and periodontal disease. Liu 2022 · Liu Lu, Xiao Zunsheng, et al. · American journal of translational research PMID:36247296 | 2022 | 1 | 1 | not extracted yet |
| MicroRNA-28-5p as a potential diagnostic biomarker for chronic periodontitis and its role in cell proliferation and inflammatory response. Huang 2022 · Huang Pengcheng, Jia Linghui · Journal of dental sciences PMID:36299340 | 2022 | 1 | none stated | not extracted yet |
| Role of miRNA-155 in the regulation of osteoclast differentiation mediated by MITF in stage III/IV periodontitis: a case-control study. Nandipati 2022 · Nandipati Sowmya Reddy, Appukuttan Devapriya, et al. · Journal, genetic engineering & biotechnology PMID:36459254 | 2022 | 1 | 1 | not extracted yet |
| Evaluation of serum and gingival crevicular fluid microRNA-223, microRNA-203 and microRNA-200b expression in chronic periodontitis patients with and… Elazazy 2021 · Elazazy Ola, Amr Khalda, et al. · Archives of Oral Biology DOI:10.1016/j.archoralbio.2020.104949 | 2021 | 1 | 1 | not extracted yet |
| Analysis of periodontitis-associated miRNAs in gingival tissue, gingival crevicular fluid, saliva and blood plasma Rovas 2021 · Rovas Adomas, Puriene Alina, et al. · Archives of Oral Biology DOI:10.1016/j.archoralbio.2021.105125 | 2021 | 1 | none stated | not extracted yet |
| The expression and clinical significance of miR-1226 in patients with periodontitis Du 2021 · Du Yimin, Qi Yue-sun, et al. · BMC Oral Health DOI:10.1186/s12903-021-01855-y | 2021 | 1 | none stated | not extracted yet |
| Evaluation of serum and gingival crevicular fluid microRNA-223, microRNA-203 and microRNA-200b expression in chronic periodontitis patients with and… Elazazy 2021 · Elazazy Ola, Amr Khalda, et al. · Archives of oral biology PMID:33157494 | 2021 | 1 | 1 | not extracted yet |
| Analysis of periodontitis-associated miRNAs in gingival tissue, gingival crevicular fluid, saliva and blood plasma. Rovas 2021 · Rovas Adomas, Puriene Alina, et al. · Archives of oral biology PMID:33862403 | 2021 | 1 | none stated | not extracted yet |
| Expression of miR-155 and miR-146a in the saliva of patients with periodontitis and its clinical value. Wu 2021 · Wu Peng, Feng Jie, et al. · American journal of translational research PMID:34306411 | 2021 | 1 | none stated | not extracted yet |
| miR-205 and HMGB1 expressions in chronic periodontitis patients and their associations with the inflammatory factors. Jiang 2021 · Jiang Fan, Zhou Yanling, et al. · American journal of translational research PMID:34540038 | 2021 | 1 | none stated | not extracted yet |
| The expression and clinical significance of miR-1226 in patients with periodontitis. Du 2021 · Du Yimin, Qi Yue-Sun, et al. · BMC oral health PMID:34592963 | 2021 | 1 | none stated | not extracted yet |
| Serum microRNAs and chronic periodontitis: A case-control study Yoneda 2019 · Yoneda Toshiki, Tomofuji Takaaki, et al. · Archives of Oral Biology DOI:10.1016/j.archoralbio.2019.03.009 | 2019 | 1 | none stated | not extracted yet |
| The Periodontal‐Cardiovascular alliance: Evaluation of miRNA‐146a in subgingival plaque samples of chronic periodontitis patients with and without… Yagnik 2019 · Yagnik Krutika, Mahendra Jaideep, et al. · Journal of Investigative and Clinical Dentistry DOI:10.1111/jicd.12442 | 2019 | 1 | none stated | not extracted yet |
| Serum microRNAs and chronic periodontitis: A case-control study. Yoneda 2019 · Yoneda Toshiki, Tomofuji Takaaki, et al. · Archives of oral biology PMID:30889506 | 2019 | 1 | none stated | not extracted yet |
| The Periodontal-Cardiovascular alliance: Evaluation of miRNA-146a in subgingival plaque samples of chronic periodontitis patients with and without… Yagnik 2019 · Yagnik Krutika, Mahendra Jaideep, et al. · Journal of investigative and clinical dentistry PMID:31338994 | 2019 | 1 | none stated | not extracted yet |
| Micro<scp>RNA</scp>‐146a and micro<scp>RNA</scp>‐155 as novel crevicular fluid biomarkers for periodontitis in non‐diabetic and type 2 diabetic… Radović 2018 · Radović Nikola, Nikolić Jakoba Nataša, et al. · Journal of Clinical Periodontology DOI:10.1111/jcpe.12888 | 2018 | 1 | 2 | not extracted yet |
| MicroRNA-146a and microRNA-155 as novel crevicular fluid biomarkers for periodontitis in non-diabetic and type 2 diabetic patients. Radovic 2018 · Radović Nikola, Nikolić Jakoba Nataša, et al. · Journal of clinical periodontology PMID:29517812 | 2018 | 1 | 2 | not extracted yet |